       Document 0224
 DOCN  M9640224
 TI    Neutralizing and infection-enhancing antibody responses to human
       immunodeficiency virus type 1 in long-term nonprogressors.
 DT    9604
 AU    Montefiori DC; Pantaleo G; Fink LM; Zhou JT; Zhou JY; Bilska M; Miralles
       GD; Fauci AS; Department of Surgery, Duke University Medical Center,
       Durham,; North Carolina 27710, USA.
 SO    J Infect Dis. 1996 Jan;173(1):60-7. Unique Identifier : AIDSLINE
       MED/96132464
 AB    Serum antibodies from human immunodeficiency virus type 1
       (HIV-1)-infected long-term non-progressors (LTNPs) and non-LTNPs were
       evaluated for virus neutralization and infection enhancement in vitro.
       Sera from LTNPs had higher average titers of neutralizing antibodies to
       HIV-1 strains IIIB and MN and more frequently neutralized primary
       isolates from progressors (14.9% vs. 1.3%, P = .002).
       Replication-competent HIV-1 was isolated from peripheral blood
       mononuclear cells and lymph nodes of 3 LTNPs. All viruses from LTNPs had
       a non-syncytium-inducing phenotype, were resistant to neutralization by
       autologous serum obtained at the time of virus isolation, and showed
       little evidence of a heightened sensitivity to neutralization by
       heterologous sera. Complement-mediated, antibody-dependent enhancement
       (C'-ADE) of HIV-1IIIB and primary isolates was equally prevalent for
       sera from LTNPs and non-LTNPs. Results indicate that LTNPs produce
       vigorous serum antibody responses and that long-term nonprogression is
       not associated with homologous neutralization or the absence of C'-ADE.
 DE    Adult  Complement Membrane Attack Complex/IMMUNOLOGY  Cytotoxicity,
       Immunologic/IMMUNOLOGY  CD4 Lymphocyte Count  Disease Progression
       Female  Human  HIV Antibodies/*ANALYSIS  HIV Antigens/IMMUNOLOGY  HIV
       Infections/*IMMUNOLOGY  HIV Seropositivity/IMMUNOLOGY
       HIV-1/*IMMUNOLOGY/ISOLATION & PURIF  Immunophenotyping  Leukocytes,
       Mononuclear/VIROLOGY  Lymph Nodes/VIROLOGY  Male  Middle Age
       Neutralization Tests  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

