       Document 0221
 DOCN  M9640221
 TI    Factors associated with cytomegalovirus infection among human
       immunodeficiency virus type 1-seronegative and -seropositive women from
       an urban minority community.
 DT    9604
 AU    Clarke LM; Duerr A; Feldman J; Sierra MF; Daidone BJ; Landesman SH;
       Department of Pathology, State University of New York Health; Science
       Center at Brooklyn 11203, USA.
 SO    J Infect Dis. 1996 Jan;173(1):77-82. Unique Identifier : AIDSLINE
       MED/96132466
 AB    Cytomegalovirus (CMV) seroprevalence and genital tract shedding in human
       immunodeficiency virus (HIV)-seronegative and HIV-seropositive women
       from an urban minority community were investigated. CMV seropositivity
       was high in both groups: 181 (95.2%) of 190 HIV-negative and 158 (90.3%)
       of 175 HIV-positive subjects. Cervicovaginal shedding was detected in 8
       (4.4%) CMV-positive HIV-negative subjects and 31 (19.6%) HIV-positive
       subjects (odds ratio [OR], 5.28; P < .001). Multiple logistic regression
       analysis revealed that CMV shedding was independently associated with
       younger age (OR = 0.90; P < .001) and concurrent Chlamydia trachomatis
       or Neisseria gonorrhoeae infection (OR = 3.60; P = .08). However,
       shedding was observed over a broad age range in HIV-positive subjects,
       with 54.8% of shedders being > or = 30 years old. Among HIV-positive
       subjects, CMV shedding was also associated with decreased CD4 cell
       counts (P = .04) and, compared with HIV-negative subjects, was
       significantly higher (P < .001) among subjects with CD4 cell counts <
       500 x 10(6)/L (26.5% in subjects with counts < or = 200 and 22.1% in
       subjects with counts of 201-499 x 10(6)/L).
 DE    Adult  AIDS-Related Opportunistic Infections/COMPLICATIONS/*EPIDEMIOLOGY
       Chlamydia trachomatis/ISOLATION & PURIF  Chlamydia
       Infections/COMPLICATIONS  Comparative Study  Cross-Sectional Studies
       Cytomegalovirus/ISOLATION & PURIF  Cytomegalovirus
       Infections/COMPLICATIONS/*EPIDEMIOLOGY  CD4 Lymphocyte Count  Female
       Gonorrhea/COMPLICATIONS  Human  *HIV Seronegativity  HIV
       Seropositivity/*COMPLICATIONS  *HIV-1  *Minority Groups  Neisseria
       gonorrhoeae/ISOLATION & PURIF  New York City/EPIDEMIOLOGY  Prevalence
       Regression Analysis  Risk Factors  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  Urban Population
       Vagina/VIROLOGY  Virus Shedding  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

