       Document 0214
 DOCN  M9640214
 TI    High numbers of T cells in gingiva from patients with human
       immunodeficiency virus (HIV) infection.
 DT    9604
 AU    Odden K; Schenck K; Hurlen B; Department of Oral Biology, Dental
       Faculty, University of Oslo,; Norway.
 SO    J Oral Pathol Med. 1995 Oct;24(9):413-9. Unique Identifier : AIDSLINE
       MED/96122624
 AB    A quantitative, immunohistologic evaluation of CD3+, CD4+ and CD8+ cells
       was carried out on gingival biopsies from 25 HIV-infected persons with
       gingivitis or periodontitis and 13 HIV-seronegative persons with
       periodontitis. CD3+ T cells were found in all biopsies. CD8+ cells were
       significantly more numerous and the CD4+/CD8+ ratio was significantly
       decreased in the gingival connective tissue of the HIV+ patients (p <
       0.05). The number of CD4+ lymphocytes subjacent to the pocket epithelium
       was moderately lower in the HIV+ patients as compared to the HIV
       patients (p < 0.05). HIV+ patients with a history of necrotizing
       periodontal disease had fewer CD4+ cells subjacent to the oral gingival
       epithelium than patients without such disease (p < 0.05). The general
       HIV-related changes in T lymphocyte numbers were therefore reflected in
       inflamed gingival tissues. HIV+ patients had, however, significantly
       higher CD4+/CD8+ ratios in gingiva than in peripheral blood (p < 0.05),
       indicating that CD4+ T cells are actively recruited to gingiva, even in
       cases of extreme CD4+ T lymphocytopenia.
 DE    Adult  Aged  Antiviral Agents/THERAPEUTIC USE  Biopsy  Comparative Study
       Connective Tissue/PATHOLOGY  CD4 Lymphocyte Count  CD4-CD8 Ratio
       CD4-Positive T-Lymphocytes/PATHOLOGY  CD8-Positive
       T-Lymphocytes/PATHOLOGY  Epithelium/PATHOLOGY  Female
       Gingiva/*PATHOLOGY  Gingivitis/*PATHOLOGY  Human  HIV
       Infections/BLOOD/DRUG THERAPY/*PATHOLOGY  HIV Seronegativity
       *Lymphocyte Count  Lymphopenia/BLOOD/PATHOLOGY  Male  Middle Age
       Periodontal Pocket/PATHOLOGY  Periodontitis/*PATHOLOGY
       T-Lymphocytes/*PATHOLOGY  T-Lymphocytes, Helper-Inducer/PATHOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

