       Document 0212
 DOCN  M9640212
 TI    [Gene structure and transformation mechanism of HTLV-I]
 DT    9604
 AU    Matsumoto K; Osaka Red Cross Blood Center.
 SO    Nippon Rinsho. 1995 Nov;53(11):2837-45. Unique Identifier : AIDSLINE
       MED/96081684
 AB    HTLV-I is the etiological agent of the adult T cell leukemia. HTLV-I
       genome contains the novel pX region in addition to the genes common to
       all retroviruses. Tax, encoded at the pX region, may play a central role
       in cellular transformation, however, little information is available on
       the mechanism. Tax transactivates transcription through three different
       pathways, namely, CRE, kB motif and CArG box mediated pathways. In ras
       cooperative focus formation in REF, transcriptional activation through
       the CArG box seems to play an important role, although transcription
       through the CRE pathway plays a central role in tax-mediated
       transformation of Rat-2 cells. These results suggest that the mechanism
       of transformation by tax varies with the cell type and/or the property
       of transformation.
 DE    Animal  *Cell Transformation, Viral  English Abstract  Gene Expression
       Regulation, Viral  Gene Products, tax/*GENETICS  Genes, pX  *Genes,
       Structural, Viral  Human  HTLV-I/*GENETICS  Trans-Activation (Genetics)
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

