       Document 0194
 DOCN  M9640194
 TI    Post-transcriptional transactivation of human retroviral envelope
       glycoprotein expression by herpes simplex virus Us11 protein [see
       comments]
 DT    9604
 AU    Diaz JJ; Dodon MD; Schaerer-Uthurralt N; Simonin D; Kindbeiter K;
       Gazzolo L; Madjar JJ; Universite Claude Bernard, Lyon-1/CNRS UMR30,
       Faculte de; Medecine, Lyon, France.
 SO    Nature. 1996 Jan 18;379(6562):273-7. Unique Identifier : AIDSLINE
       MED/96138386
 CM    Comment in: Nature 1996 Jan 18;379(6562):208
 AB    Herpes simplex virus type 1 (HSV-1) Us11 protein, a true late gene
       product packaged within the virion, is delivered into cells after
       infection, exhibits a nucleocytoplasmic localization at early times, and
       later accumulates in the nucleoli. This RNA-binding basic
       phosphoprotein, capable of oligomerization, is supposed to be involved
       in post-transcriptional regulation of gene expression after HSV-1
       infection. Expression of human T-cell leukaemia/lymphoma virus type-I
       (HTLV-I) and of human immunodeficiency virus type 1 (HIV-1) is
       post-transcriptionally regulated by Rex and Rev, respectively. These
       proteins are required for the cytoplasmic expression of unspliced
       gag-pol and singly spliced env transcripts. Here we show that HSV-1 Us11
       protein is able to bind Rex- and Rev-responsive elements and to
       transactivate envelope retroviral glycoprotein expression.
 DE    Cytoplasm/METABOLISM  *Gene Expression Regulation, Viral  Gene Products,
       rev/GENETICS/PHYSIOLOGY  Gene Products, rex/GENETICS/PHYSIOLOGY  Gene
       Products, tax/GENETICS  Giant Cells/VIROLOGY  Hela Cells  Herpesvirus 1,
       Human/*GENETICS  Human  HIV-1/*GENETICS  HTLV-I/*GENETICS  RNA-Binding
       Proteins/GENETICS/*PHYSIOLOGY  RNA, Messenger/METABOLISM  RNA,
       Viral/METABOLISM  Support, Non-U.S. Gov't
       Trans-Activators/GENETICS/*PHYSIOLOGY  Transfection  Viral Envelope
       Proteins/*GENETICS  Viral Proteins/GENETICS/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

