       Document 0193
 DOCN  M9640193
 TI    Serum secretory IgA and IgM and free secretory component in IgA
       nephropathy.
 DT    9604
 AU    Mole CM; Renoult E; Bene MC; Seilles E; Kessler M; Revillard JP; Faure
       GC; GRIP, Jeune Equipe DRED 251, Laboratoire d'Immunologie Faculte; de
       Medecine, CHU Nancy, France.
 SO    Nephron. 1995;71(1):75-8. Unique Identifier : AIDSLINE MED/96042417
 AB    IgA nephropathy (IgAN) is characterized by the presence of IgA and C3
       deposits in the mesangium. Mesangial IgA is mostly dimeric IgA1 with a J
       chain, lacking a secretory component. In view of the recent
       demonstration of elevated serum levels of secretory component and
       secretory IgA in liver disease and HIV infection associated with
       hyper-IgA, we measured the serum secretory component in 50 IgAN patients
       and 45 controls. Free secretory component and secretory IgA and IgM
       levels were determined by enzyme-linked immunosorbent assay. Normal or
       low levels were found patients. These data support previous work
       suggesting that in IgAN circulating and probably mesangial IgA do not
       originate from the epithelial compartment of the mucosal immunoglobulins
       as it is the case in other hyper-IgA diseases.
 DE    Adolescence  Adult  Aged  Enzyme-Linked Immunosorbent Assay  Female
       Glomerulonephritis, IGA/*BLOOD  Human  IgA, Secretory/*BLOOD  IgM/*BLOOD
       Male  Middle Age  Secretory Component/*BLOOD  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

