       Document 0178
 DOCN  M9640178
 TI    Randomized study of sulfamethoxazole-trimethoprim versus aerosolized
       pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia
       in patients with AIDS.
 DT    9604
 AU    Nielsen TL; Jensen BN; Nelsing S; Mathiesen LR; Skinhoj P; Nielsen JO;
       Department of Infectious Diseases, University Hospital Hvidovre,;
       Copenhagen, Denmark.
 SO    Scand J Infect Dis. 1995;27(3):217-20. Unique Identifier : AIDSLINE
       MED/96143360
 AB    In a prospective, randomized open-label trial, the efficacy of
       sulfamethoxazole-trimethoprim (SMX-TMP) 400/80 mg b.i.d. was compared
       with the efficacy of aerosolized pentamidine (AP) 60 mg every 2nd week
       as secondary prophylaxis (SP) against recurrence of Pneumocystis carinii
       pneumonia (PCP) in AIDS patients. 94 patients participated in the study,
       47 in each group. The patients were observed for a mean period of 17.2
       months. PCP recurred in the AP group in 8 cases, while 1 relapse
       occurred in the SMX-TMP group. The one-year cumulative relapse rate was
       9.0% (95% CI 0-19%) in the AP group compared with 2.4% (95% CI 0-8%) in
       the SMX-TMP group (p < 0.05). The odds ratio was 4.2 (95% CI 0.5-39.8)
       in favour of SMX-TMP. Furthermore, we found a tendency towards a
       protective effect against toxoplasmosis in the SMX-TMP group, though
       there was no difference in survival between the two groups. There was no
       statistical difference in frequency of crossover from one therapy form
       to the other. Based on these data we recommend SMX-TMP for secondary PCP
       prophylaxis.
 DE    Administration, Inhalation  Administration, Oral  Adult  Aerosols  Aged
       Anti-Infective Agents/ADVERSE EFFECTS/*THERAPEUTIC USE  Antifungal
       Agents/ADVERSE EFFECTS/*THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/ETIOLOGY/*PREVENTION &  CONTROL  Comparative Study  Female
       Human  Male  Middle Age  Nebulizers and Vaporizers  Pentamidine/ADVERSE
       EFFECTS/*THERAPEUTIC USE  Pneumonia, Pneumocystis
       carinii/ETIOLOGY/*PREVENTION & CONTROL  Premedication  Prospective
       Studies  Recurrence  Toxoplasmosis/DRUG THERAPY/ETIOLOGY
       Trimethoprim-Sulfamethoxazole Combination/ADVERSE EFFECTS/  *THERAPEUTIC
       USE  CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

