       Document 0175
 DOCN  M9640175
 TI    [HIV and pregnancy]
 DT    9604
 AU    Rudin C; Camli C; Schnuriger H; Biedermann K; Lauper U; Kind C;
       Universitats-Kinderklinik Basel.
 SO    Schweiz Med Wochenschr. 1995 Dec 2;125(48):2322-9. Unique Identifier :
       AIDSLINE MED/96105969
 AB    Since 1990 216 HIV-infected pregnant women have been enrolled in an
       ongoing nationwide study named HIV and Pregnancy financed by the Swiss
       Federal Office of Health (No. 90-7007 and 93-7131). Of a total of 228
       recorded pregnancies 154 continued to parturition. Until now it has been
       definitively established whether or not 89 offsprings have been infected
       with HIV by their mothers. According to clinical and immunological
       findings most of the pregnant women are still in early, stable stages of
       HIV-infection (stages II and III of the CDC classification system in 94%
       of the subjects; mean CD4-cell count around 600/microliters). HIV
       infection was the consequence of an intravenous substance abuse in two
       thirds of the women. Detailed interviews revealed an alarming negligence
       with regard to compliance with safer sex recommendations and
       contraception. Advisory services of specialized AIDS information centers
       have very rarely been called on. In our group, the vertical transmission
       rate shows a statistically significant correlation with low maternal
       anti-HIV-p24 antibody titers, high serum neopterin- and
       IgA-concentrations, and also with the use of forceps and vacuum in
       vaginal delivery. Maternal substance abuse but not HIV infection itself
       resulted in an incidence of preterm deliveries roughly twice as high as
       in the normal Swiss population.
 DE    Abortion, Induced  Adult  Disease Transmission, Vertical  English
       Abstract  Female  Human  HIV
       Infections/CONGENITAL/*COMPLICATIONS/EPIDEMIOLOGY/  TRANSMISSION
       Infant, Newborn  Patient Education  Pregnancy  *Pregnancy Complications,
       Infectious  Prospective Studies  Sex Behavior  Substance Abuse,
       Intravenous/COMPLICATIONS  Support, Non-U.S. Gov't
       Switzerland/EPIDEMIOLOGY  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

