       Document 0131
 DOCN  M9640131
 TI    Treatment of AIDS-related lymphomas.
 DT    9604
 AU    Sparano JA; Albert Einstein Cancer Center, Bronx, NY, USA.
 SO    Curr Opin Oncol. 1995 Sep;7(5):442-9. Unique Identifier : AIDSLINE
       MED/96076280
 AB    Infection with HIV is associated with an increased risk of systemic and
       primary central nervous system non-Hodgkin's lymphoma. Patients with
       systemic non-Hodgkin's lymphoma usually present with high- or
       intermediate-grade histology and extranodal dissemination. Although the
       prognosis for such patients is poor, some patients clearly benefit from
       combination chemotherapy, and several new treatment approaches appear
       promising. Primary central nervous system lymphoma usually occurs in
       patients with more profound immunosuppression and is associated with a
       dismal prognosis. Selected patients with good performance status may
       benefit from therapy, particularly if opportunistic infections have been
       few and nondebilitating. Finally, Hodgkin's disease has been reported in
       patients with HIV infection, particularly in patients with a history of
       intravenous drug use, and it is more likely to present with
       advanced-stage disease and unfavorable histology.
 DE    Central Nervous System Neoplasms/EPIDEMIOLOGY/PATHOLOGY/THERAPY
       Clinical Trials  Hodgkin's Disease/EPIDEMIOLOGY/THERAPY  Human
       Lymphoma, AIDS-Related/*THERAPY  Lymphoma,
       Non-Hodgkin's/EPIDEMIOLOGY/PATHOLOGY/THERAPY  Multicenter Studies
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

