       Document 0129
 DOCN  M9640129
 TI    Electrical stimulation of the sciatic nerve alters neuropeptide content
       and lymphocyte migration in the subcutaneous tissue of the rat hind paw.
 DT    9604
 AU    Herzberg U; Murtaugh MP; Mullet MA; Beitz AJ; Department of Veterinary
       PathoBiology, University of Minnesota,; St. Paul 55108, USA.
 SO    Neuroreport. 1995 Sep 11;6(13):1773-7. Unique Identifier : AIDSLINE
       MED/96098653
 AB    To study the possible mechanism by which peripheral nerves mediate
       immune responses in target tissues, electrical stimulation of the
       sciatic nerve was combined with subcutaneous microdialysis of the hind
       paw. Following unilateral stimulation of the sciatic nerve, an
       ipsilateral rise in substance P and a bilateral rise in VIP levels were
       observed in dialysate samples from experimental vs control animals.
       Electrical stimulation of the sciatic nerve induced a marked hyperemia
       and swelling of the ipsilateral paw. Quantitative immunocytochemical
       analysis of paraffin-embedded sections of the hind foot pads
       demonstrated T lymphocyte migration ipsilateral to the stimulated nerve.
       These findings suggest that peripheral nerves can directly modulate
       local immune and inflammatory responses.
 DE    Animal  Cell Movement/*PHYSIOLOGY  CD4-Positive T-Lymphocytes/CYTOLOGY
       CD8-Positive T-Lymphocytes/CYTOLOGY  Electric Stimulation  Hindlimb
       Microdialysis  Neuropeptides/*METABOLISM  Radioimmunoassay  Rats
       Sciatic Nerve/*PHYSIOLOGY  Substance P/*METABOLISM  Support, U.S. Gov't,
       P.H.S.  T-Lymphocytes/*CYTOLOGY  Vasoactive Intestinal
       Peptide/*METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

