       Document 0089
 DOCN  M9640089
 TI    Clinical and histopathologic features of hair loss in patients with
       HIV-1 infection.
 DT    9604
 AU    Smith KJ; Skelton HG; DeRusso D; Sperling L; Yeager J; Wagner KF;
       Angritt P; United States Army Medical Research Institute for Chemical;
       Defense, Aberdeen, Maryland, USA.
 SO    J Am Acad Dermatol. 1996 Jan;34(1):63-8. Unique Identifier : AIDSLINE
       MED/96140324
 AB    BACKGROUND: Hair loss is common in patients with HIV-1 infection, and in
       black patients this loss may be associated with straightening. Possible
       causes are frequently present in patients with HIV-1. These causes
       include chronic HIV-1 infection itself and recurrent secondary
       infections, nutritional deficiencies, immunologic and endocrine
       dysregulation, and exposure to multiple drugs. However, histopathologic
       features have rarely been reported in these patients. OBJECTIVE: The
       objective was to evaluate the changes in the hairs of a group of these
       patients and to identify the light microscopic and ultrastructural
       changes in the hairs and the histologic changes in the scalp. METHODS:
       Hair plucks and pulls with scanning electron microscopy of the hairs
       were done on 10 patients with late-stage HIV-1 infection. In addition,
       scalp biopsy specimens were examined in both vertical and transverse
       sections. RESULTS: All patients had telogen effluvium. Numerous
       apoptotic or necrotic keratinocytes were seen in the upper external root
       sheath follicular epithelium in addition to a mild to moderate
       perifollicular mononuclear cell infiltrate often containing eosinophils.
       Variable dystrophy of the hair shafts was also a consistent feature.
       CONCLUSION: Although telogen effluvium is a common response to a wide
       spectrum of biologic stresses, the presence of apoptotic or necrotic
       keratinocytes within the upper end of the external root sheath
       epithelium and dystrophy of hairs may be markers of hair loss in
       patients with HIV-1 infection.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS
       Alopecia/ETIOLOGY/*PATHOLOGY  Apoptosis  Female  Hair/*ULTRASTRUCTURE
       Human  *HIV-1  Keratinocytes/PATHOLOGY  Male  Scalp/*PATHOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

