       Document 0088
 DOCN  M9640088
 TI    Clinical and histologic spectrum of human T-cell lymphotropic virus type
       I-associated lymphoma involving the skin.
 DT    9604
 AU    DiCaudo DJ; Perniciaro C; Worrell JT; White JW Jr; Cockerell CJ;
       Department of Dermatology, Mayo Clinic, Rochester, Minnesota,; USA.
 SO    J Am Acad Dermatol. 1996 Jan;34(1):69-76. Unique Identifier : AIDSLINE
       MED/96140325
 AB    BACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is associated with
       infection with human T-cell lymphotropic virus type I (HTLV-I).
       OBJECTIVE: The objective was to describe the clinical, histopathologic,
       and immunologic features in three patients with ATL involving the skin.
       METHODS: Clinical histories and skin biopsy specimens were reviewed.
       Immunophenotypic studies were performed on peripheral blood lymphocytes
       (three patients) and on skin biopsy specimens (one patient). RESULTS:
       Serologic testing in each patient was positive for HTLV-I. Specific
       cutaneous lesions of ATL were diverse. Histologic features included
       markedly epidermotropic lymphoid infiltrates and dermal aggregates of
       lymphocytes and macrophages resembling granulomas. One patient died 3
       months after diagnosis; the other two are alive with residual lymphoma.
       CONCLUSION: A spectrum of clinical, histologic, and immunophenotypic
       features are seen in ATL involving skin. Those cases with a chronic
       course may resemble mycosis fungoides clinically and histologically.
       Serologic testing for HTLV-I is recommended in all patients with
       cutaneous lymphoma from endemic areas and in those with other risk
       factors for HTLV-I infection.
 DE    Adult  Case Report  Female  Human  HTLV-I Antibodies/ANALYSIS
       Immunophenotyping  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/IMMUNOLOGY/  *PATHOLOGY  Middle Age  Skin
       Neoplasms/IMMUNOLOGY/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

