       Document 0072
 DOCN  M9640072
 TI    Neurophysiological evaluation of zidovudine in asymptomatic HIV-1
       infection: a longitudinal placebo-controlled study.
 DT    9604
 AU    Baldeweg T; Riccio M; Gruzelier J; Hawkins D; Burgess A; Irving G;
       Stygall J; Catt S; Catalan J; Academic Department of Psychiatry, Charing
       Cross and Westminster; Medical School, London, UK.
 SO    J Neurol Sci. 1995 Oct;132(2):162-9. Unique Identifier : AIDSLINE
       MED/96098605
 AB    The effect of early antiretroviral medication with zidovudine on
       neurophysiological functions was evaluated in subjects with asymptomatic
       HIV-1 infection. Patients were recruited participants of a larger
       double-blind randomised placebo-controlled treatment trial with
       zidovudine (Concorde). The main outcome measures included: quantitative
       electroencephalography (QEEG), auditory event-related potentials (AEP)
       and pattern-reversal visual evoked potentials (PRVEP), as well as
       standard clinical, virological and immunological markers. No significant
       impairment and no difference between treatment groups was found in
       visual P100 latency and auditory long-latency P3 responses which is in
       agreement with the absence of neurological and neuropsychological
       impairment over the study period. Significant treatment effects were
       revealed by quantitative electroencephalography (QEEG). While the
       placebo group showed a significant increase in delta and theta slow
       frequency QEEG activity over the study period, slow wave amplitude
       remained unchanged in the zidovudine group after a mean follow-up period
       of 28 months. In summary, the data provide evidence for a low level
       neuropathological process in asymptomatic HIV-1 infection which can be
       effectively suppressed by antiretroviral medication.
 DE    Adult  Antiviral Agents/*THERAPEUTIC USE  CD4 Lymphocyte Count
       Double-Blind Method  Electroencephalography  Evoked Potentials,
       Auditory/DRUG EFFECTS/PHYSIOLOGY  Evoked Potentials, Visual/DRUG
       EFFECTS/PHYSIOLOGY  Human  HIV Infections/*DRUG
       THERAPY/*PHYSIOPATHOLOGY/PSYCHOLOGY  HIV Seropositivity/*DRUG
       THERAPY/*PHYSIOPATHOLOGY/PSYCHOLOGY  *HIV-1  Longitudinal Studies  Male
       Neuropsychological Tests  Support, Non-U.S. Gov't
       Zidovudine/*THERAPEUTIC USE  CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED
       CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

