       Document 0063
 DOCN  M9640063
 TI    Transmission of tuberculosis among the urban homeless.
 DT    9604
 AU    Barnes PF; el-Hajj H; Preston-Martin S; Cave MD; Jones BE; Otaya M;
       Pogoda J; Eisenach KD; Department of Medicine, University of Southern
       California School; of Medicine, Los Angeles 90033, USA.
 SO    JAMA. 1996 Jan 24-31;275(4):305-7. Unique Identifier : AIDSLINE
       MED/96144538
 AB    OBJECTIVE--To determine the relative frequencies of primary and
       reactivation tuberculosis in the urban homeless. DESIGN--Prospective
       evaluation of homeless tuberculosis patients. SETTING--Central Los
       Angeles, Calif. PATIENTS--Thirty-four homeless patients with
       culture-proven tuberculosis. INTERVENTIONS--IS6110-based restriction
       fragment length polymorphism (RFLP) analysis was performed on
       Mycobacterium tuberculosis isolates. If results were inconclusive,
       pTBN12-based RFLP analysis was performed. MAIN OUTCOME
       MEASURE--Clustering of M tuberculosis isolates. A cluster consisted of
       two or more isolates with indistinguishable RFLP patterns.
       RESULTS--Twenty-four of 34 homeless patients had clustered isolates in
       six clusters. CONCLUSIONS--The minimum percentage of cases due to
       primary tuberculosis in the homeless was estimated to be 53%, compared
       with the traditional estimate of 10% in the general population. The
       results suggest that primary tuberculosis caused the majority of
       tuberculosis cases in this population of the urban homeless in central
       Los Angeles.
 DE    Adult  Female  *Homeless Persons/STATISTICS & NUMER DATA  Human  HIV
       Infections/COMPLICATIONS/EPIDEMIOLOGY  Los Angeles/EPIDEMIOLOGY  Male
       Middle Age  Mycobacterium tuberculosis/*ISOLATION & PURIF  Polymorphism,
       Restriction Fragment Length  Prospective Studies  Recurrence  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Tuberculosis/COMPLICATIONS/DIAGNOSIS/*EPIDEMIOLOGY/TRANSMISSION  Urban
       Population/STATISTICS & NUMER DATA  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

