       Document 0055
 DOCN  M9640055
 TI    Short echo time proton spectroscopy of the brain in HIV infection/AIDS.
 DT    9604
 AU    Paley M; Wilkinson ID; Hall-Craggs MA; Chong WK; Chinn RJ; Harrison MJ;
       MRI Unit, Middlesex Hospital, University College London; Hospitals, UK.
 SO    Magn Reson Imaging. 1995;13(6):871-5. Unique Identifier : AIDSLINE
       MED/96122886
 AB    Short echo time proton spectra have been acquired from the brains of 30
       male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and
       12 age-matched control subjects on a 1.5 T MR system. The acquisition
       protocol used stimulated acquisition voxel localisation with a voxel
       size of 8 ml and repeat, echo, and mixing times of 5000, 20, and 30 ms,
       respectively. A single 25.6-ms Gaussian water suppression pulse was used
       with 128 spectral acquisitions and the data were eddy current corrected
       using a water reference. Baseline-corrected spectra were nonlinearly
       least squares fitted to a model function consisting of Gaussian
       functions representing the major metabolites reported in short echo
       proton spectra. Results indicate that the N-acetyl/creatine (NA/Cr)
       ratio is significantly reduced by 20% in AIDS patients [NA/Cr = 1.91
       (0.51)] compared to control subjects [NA/Cr = 2.37 (0.25)] at short echo
       times.
 DE    Adult  AIDS Dementia Complex/*METABOLISM  Brain/*METABOLISM  Human  Male
       Nuclear Magnetic Resonance/*METHODS  CLINICAL TRIAL  CONTROLLED CLINICAL
       TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

