       Document 0054
 DOCN  M9640054
 TI    Threshold analysis and programs for prevention of HIV infection.
 DT    9604
 AU    Holtgrave DR; Qualls NL; Office of HIV/AIDS, Centers for Disease Control
       and Prevention; (CDC), Atlanta, Georgia, USA.
 SO    Med Decis Making. 1995 Oct-Dec;15(4):311-7. Unique Identifier : AIDSLINE
       MED/96116981
 AB    BACKGROUND. Measuring the economic effectiveness of HIV-infection
       prevention activities poses special challenges in terms of behavioral
       change and health outcomes assessment. METHODS. One way to address this
       difficulty is to employ threshold analysis to determine a level of cost
       per HIV infection averted above which society would seem unwilling to
       pay. The authors employ a cost-utility analytic framework to determine a
       monetary threshold for HIV prevention programs, subject base-case
       results to sensitivity analyses, and apply these results to the Centers
       for Disease Control and Prevention's fiscal year 1993 budget for
       extramural HIV prevention programs. RESULTS. The monetary threshold for
       cost per HIV infection averted was calculated to be $417,000 in 1993
       dollars, and ranged from $185,000 to $648,000 depending upon the dollar
       amount society would be willing to pay per quality-adjusted life year
       gained. CONCLUSIONS. Economic evaluations of particular HIV-infection
       prevention activities at least can begin by determining whether their
       levels of effectiveness are above or below this derived monetary
       threshold, and refinements beyond this dichotomous evaluation can
       proceed as further data become available.
 DE    Adult  Aged  Centers for Disease Control and Prevention (U.S.)
       Cost-Benefit Analysis  Health Behavior  Human  HIV
       Infections/*ECONOMICS/*PREVENTION & CONTROL  Middle Age  *Models,
       Econometric  Outcome Assessment (Health Care)  Primary
       Prevention/*ECONOMICS  Program Evaluation  Quality-Adjusted Life Years
       Sensitivity and Specificity  United States  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

