       Document 0040
 DOCN  M9640040
 TI    [Nonketotic hyperglycemic coma induced by somatostatin in an AIDS
       patient]
 DT    9604
 AU    Vandercam B; Hermans MP; Coumans P; Jacques D; Gala JL; Kolanowski J;
       Departement de Medecine interne, Cliniques Universitaires; Saint-Luc,
       Bruxelles, Belgique.
 SO    Presse Med. 1995 Oct 14;24(30):1389-90. Unique Identifier : AIDSLINE
       MED/96142384
 AB    A 33-year-old woman with AIDS was treated with somatostatin (continuous
       infusion 6 mg/day) for intractable diarrhoea. Improvement was
       insufficient and the dose was increased to 12 mg/day 5 days later.
       Hyperosmolar non-ketotic coma occurred two days later (blood glucose 53
       mmol/l, bicarbonate 8 mmol/l, pH of arterial blood 7.2). Search for
       urinary ketones was negative. Klebsiella pneumonia was isolated in the
       urine sample. Somatostatin was withdrawn and the patient improved with
       parenteral nutrition and intravenous insulin. Glucose tolerance was
       verified after recovery and was normal. Somatostatin is known to impair
       glucose tolerance and as shown in this case should also be recognized as
       a cause of hyperosmolar non-ketotic coma. Increasing use of
       somatostatin, particularly in HIV patients often given other
       hyperglycaemia inducing drugs such as didanosine, pentamidine, dapsone,
       and phenytoin should be accompanied with careful monitoring of blood
       glucose levels.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Antibiotics,
       Combined/THERAPEUTIC USE  AIDS-Related Opportunistic Infections/DRUG
       THERAPY/MICROBIOLOGY  Case Report  Diarrhea/*DRUG THERAPY/ETIOLOGY
       English Abstract  Female  Hormone Antagonists/ADMINISTRATION &
       DOSAGE/*ADVERSE EFFECTS/  THERAPEUTIC USE  Human  Hyperglycemic
       Hyperosmolar Nonketotic Coma/*CHEMICALLY INDUCED  Klebsiella
       Infections/COMPLICATIONS/DRUG THERAPY/MICROBIOLOGY
       Somatostatin/ADMINISTRATION & DOSAGE/*ADVERSE EFFECTS/THERAPEUTIC  USE
       Urinary Tract Infections/COMPLICATIONS/DRUG THERAPY/MICROBIOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

