       Document 0028
 DOCN  M9640028
 TI    Sarcomas in organ allograft recipients.
 DT    9604
 AU    Penn I; Department of Surgery, University of Cincinnati Medical Center,;
       Ohio, USA.
 SO    Transplantation. 1995 Dec 27;60(12):1485-91. Unique Identifier :
       AIDSLINE MED/96125836
 AB    In a review of 8724 de novo malignancies that occurred in 8191 organ
       allograft recipients sarcomas were 7.4% of cancers. Kaposi's sarcoma
       (KS) made up 5.7%, and other sarcomas (OS) 1.7% a much higher proportion
       than in the general population. KS was most common in Arab, black,
       Italian, Jewish, or Greek patients. In 60% of patients with KS the
       lesions were confined to the skin and/or oropharynx while 40% involved
       internal organs and/or lymph nodes. Complete remissions following
       various treatments occurred in 53% of the former group and 27% of the
       latter. In both groups 32% and 60% of remissions, respectively, occurred
       when the only treatment was reduction or cessation of immunosuppressive
       therapy. However, this treatment caused impaired function or allograft
       loss from rejection in 22 of 34 kidney recipients. Recurrent KS occurred
       in 5% of patients in remission when immunosuppressive therapy was
       resumed. Nine of 114 patients (8%) tested for human immunodeficiency
       virus were positive. Most OS arose in internal organs or soft tissues.
       The major types were fibrous histiocytoma (20 patients), leiomyosarcoma
       (15), fibrosarcoma (12), rhabdomyosarcoma (9), hemangiosarcoma (8),
       undifferentiated sarcoma (7) and mesothelioma (6). Several unusual
       features were noted. Remarkably, 10 of 105 (10%) sarcomas occurred
       adjacent to or in a renal (6) or hepatic (4) allograft. Leiomyosarcomas
       are rare in children, yet 5 of 15 (33%) occurred in pediatric patients.
       Three hemangiosarcomas occurred in forearms at sites of arteriovenous
       fistulas used for pretransplant hemodialysis access. One leiomyosarcoma
       and one fibrosarcoma occurred in previously irradiated areas. One
       patient with mesothelioma had a history of asbestos exposure and two
       others had possible exposure.
 DE    Human  Organ Transplantation/*ADVERSE EFFECTS  Racial Stocks  Registries
       Sarcoma/ETHNOLOGY/*ETIOLOGY/PHYSIOPATHOLOGY  Support, U.S. Gov't,
       Non-P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW, MULTICASE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

