       Document 0024
 DOCN  M9640024
 TI    Feline immunodeficiency virus replicates in salivary gland ductular
       epithelium during the initial phase of infection.
 DT    9604
 AU    Park HS; Kyaw-Tanner M; Thomas J; Robinson WF; Department of Veterinary
       Pathology, University of Queensland,; Brisbane, Australia.
 SO    Vet Microbiol. 1995 Sep;46(1-3):257-67. Unique Identifier : AIDSLINE
       MED/96107041
 AB    Feline immunodeficiency virus (FIV) antigen was detected by
       immunochemistry in salivary glands of cats experimentally inoculated
       with West Australian isolate T91. Six cats were inoculated
       subcutaneously with 1.0 ml of tissue culture supernatant fluid from a
       feline T-lymphoblastoid cell line (MYA-1) infected with T91. FIV
       antigens were detected in the interlobular ducts of the salivary gland
       of cats infected with FIV 2, 4 and 6 weeks previously. FIV antigen was
       not detected in the salivary glands of three FIV negative cats and one
       naturally infected cat. Further, FIV antigen was located only in
       interlobular duct epithelial cells. The distribution of FIV in the
       interlobular ducts confirms the important role of salivary glands as a
       major reservoir of FIV in the early phase of infection and strengthens
       suggestions that the salivary route is an important mode of transmission
       of FIV.
 DE    Animal  Antibodies, Monoclonal  Antibodies, Viral/BLOOD  Australia  Base
       Sequence  Cats  DNA Primers  DNA, Viral/ANALYSIS/GENETICS
       Epithelium/VIROLOGY  Feline Acquired Immunodeficiency
       Syndrome/IMMUNOLOGY/  *PHYSIOPATHOLOGY  Fluorescent Antibody Technique,
       Indirect  Immunodeficiency Virus, Feline/IMMUNOLOGY/ISOLATION & PURIF/
       *PHYSIOLOGY  Immunohistochemistry  Mice  Mice, Inbred BALB C/IMMUNOLOGY
       Molecular Sequence Data  Polymerase Chain Reaction
       Proviruses/PHYSIOLOGY  Salivary Glands/*VIROLOGY  Support, Non-U.S.
       Gov't  *Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

