       Document 0023
 DOCN  M9640023
 TI    Mitochondrial abnormalities in human immunodeficiency virus-associated
       myopathy.
 DT    9604
 AU    Morgello S; Wolfe D; Godfrey E; Feinstein R; Tagliati M; Simpson DM;
       Department of Pathology (Division of Neuropathology, Mount Sinai;
       Medical Center, New York City, NY 10029, USA.
 SO    Acta Neuropathol (Berl). 1995;90(4):366-74. Unique Identifier : AIDSLINE
       MED/96105464
 AB    There is controversy as to whether zidovudine (ZDV) induces a
       mitochondrial myopathy that is distinguishable from human
       immunodeficiency virus (HIV)-associated myopathy in ZDV-naive patients.
       Mitochondrial abnormalities were evaluated in skeletal muscle obtained
       from 18 HIV-positive, ZDV-exposed patients, and 9 who were drug naive.
       All patients had clinical myopathy, and underwent neuromuscular
       evaluation with information recorded on timing and dosage of ZDV. All
       underwent muscle biopsies and samples were examined without knowledge of
       clinical history or ZDV status. Biopsy samples were evaluated by light
       and electron microscopy. Mitochondrial abnormalities were seen in
       ZDV-treated and -naive groups, and did not correlate with ZDV exposure
       or cumulative ZDV dosage. Mitochondrial abnormalities displayed
       significant correlation with the presence and severity of myofiber
       degeneration on biopsy, regardless of ZDV status. As mitochondrial
       abnormalities reflect myofiber degeneration, present in both patient
       groups, they may not be used as evidence of primary mitochondrial
       dysfunction. The etiology of myofiber degeneration in patients with HIV
       infection, whether ZDV-exposed or -naive, remains unclear.
 DE    Adult  Antiviral Agents/ADVERSE EFFECTS/THERAPEUTIC USE  Creatine
       Kinase/METABOLISM  Female  Human  HIV Infections/COMPLICATIONS/DRUG
       THERAPY/*PATHOLOGY  Male  Microscopy, Electron  Middle Age
       Mitochondria, Muscle/*ULTRASTRUCTURE  Muscle Fibers/ULTRASTRUCTURE
       Muscle Weakness/PATHOLOGY  Muscles/PATHOLOGY/ULTRASTRUCTURE  Muscular
       Diseases/ETIOLOGY/*PATHOLOGY  Pain/ETIOLOGY/PATHOLOGY  Support, U.S.
       Gov't, P.H.S.  Zidovudine/ADVERSE EFFECTS/THERAPEUTIC USE  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

