       Document 0022
 DOCN  M9640022
 TI    Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and
       reactive lymphoid tissue. Type A with a high prevalence of deletions
       within the latent membrane protein gene.
 DT    9604
 AU    Chen WG; Chen YY; Bacchi MM; Bacchi CE; Alvarenga M; Weiss LM;
       Department of Pathology, City of Hope National Medical Center,; Duarte,
       California 91010, USA.
 SO    Am J Pathol. 1996 Jan;148(1):17-23. Unique Identifier : AIDSLINE
       MED/96133074
 AB    Both Epstein-Barr virus (EBV) types A and B are found in endemic
       Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17
       cases of Brazilian BL previously demonstrated to be EBV-positive to
       determine the EBV type as well as the presence of a characteristic 30 bp
       deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene
       that may be important to the pathogenesis of several EBV-associated
       neoplasms. All cases in which the age was known were children. We found
       type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case.
       The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases,
       including the one case of type B EBV, and a similar high prevalence
       (59%) of the deletion was detected in EBV-positive normal and reactive
       lymphoid tissues from individuals from the same geographic region. The
       high proportion of cases associated with type A EBV suggests that
       immunodeficiency is not an important factor in the pathogenesis of
       Brazilian BL, in contrast to endemic African BL. The presence of the
       LMP-1 deletion in a high prevalence in the normal population in this
       region is unexplained.
 DE    Adolescence  Base Sequence  Brazil/EPIDEMIOLOGY  Burkitt's
       Lymphoma/EPIDEMIOLOGY/*VIROLOGY  Child  Female  Gene Deletion  Genes,
       Viral/GENETICS  Genotype  Herpesvirus 4, Human/*CLASSIFICATION/GENETICS
       Human  Lymphoid Tissue/VIROLOGY  Male  Molecular Sequence Data
       Polymerase Chain Reaction  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

