       Document 0021
 DOCN  M9640021
 TI    Neuronal pattern correlates with the severity of human immunodeficiency
       virus-associated dementia complex. Usefulness of spatial pattern
       analysis in clinicopathological studies.
 DT    9604
 AU    Asare E; Dunn G; Glass J; McArthur J; Luthert P; Lantos P; Everall I;
       Department of Neuropathology, Institute of Psychiatry, De; Crespigny
       Park, London, United Kingdom.
 SO    Am J Pathol. 1996 Jan;148(1):31-8. Unique Identifier : AIDSLINE
       MED/96133076
 AB    The spatial distributional pattern of neurons, in the superior frontal
       gyrus of 32 subjects who died of acquired immune deficiency syndrome,
       was examined. The patients were classified as nondemented, mildly
       demented, and severely demented, and some were treated with the
       anti-retroviral drug zidovudine. Spatial statistical techniques were
       employed to investigate the degree of clustering in the individual cases
       and various groups. We found that the cluster pattern of large and small
       neurons differed significantly with increasing severity of dementia but
       was not influenced by the duration of zidovudine treatment. We conclude
       that this is a sensitive technique for clinicopathological correlations
       and that the differences may result from loss of specific neuronal
       populations, which could determine the degree of dementia.
 DE    Antiviral Agents/THERAPEUTIC USE  AIDS Dementia
       Complex/COMPLICATIONS/*PATHOLOGY  Brain/*PATHOLOGY  Human  HIV
       Infections/*COMPLICATIONS/DRUG THERAPY  Neurons/*PATHOLOGY  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Zidovudine/THERAPEUTIC USE
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

