       Document 0020
 DOCN  M9640020
 TI    Allogeneic transfusion risks in the surgical patient.
 DT    9604
 AU    Klein HG; Department of Transfusion Medicine, Warren Grant Magnuson;
       Clinical Center, National Institutes of Health, Bethesda,; Maryland
       20892, USA.
 SO    Am J Surg. 1995 Dec;170(6A Suppl):21S-26S. Unique Identifier : AIDSLINE
       MED/96140153
 AB    The risk of blood transfusion-associated complications has been reduced
       in the past 10 years through technical advances in testing of blood,
       viral inactivation of noncellular blood components, enforcement of
       stringent donor selection criteria, and the use of alternatives to
       allogeneic transfusion. Even so, a zero-risk blood supply is unfeasible.
       The general public perceives infectious complications to be the most
       significant risk: although the greatest fear is associated with
       transmission of human immunodeficiency virus (HIV), at least three
       hepatitis viruses are transmissible by all blood components. Human
       immunodeficiency virus accounts for < 20 cases per year of
       transfusion-related acquired immunodeficiency syndrome in the United
       States. The three important noninfectious complications are
       alloimmunization, which is common but clinically insignificant;
       immunosuppression, the clinical significance of which is controversial;
       and graft-versus-host disease, a lethal complication most likely to
       affect patients who are immunosuppressed, have cancer, or are recipients
       of bone marrow transplants.
 DE    Acquired Immunodeficiency Syndrome/TRANSMISSION  Antigen-Antibody
       Reactions/IMMUNOLOGY  Blood Transfusion/*ADVERSE EFFECTS
       Erythrocytes/IMMUNOLOGY  Graft vs Host Disease/ETIOLOGY  Hepatitis,
       Viral, Human/TRANSMISSION  Human  HTLV-I Infections/TRANSMISSION  Immune
       Tolerance/IMMUNOLOGY  Risk  Transplantation, Homologous/ADVERSE
       EFFECTS/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

