       Document 0008
 DOCN  M9640008
 TI    Maternal HIV infection, drug use, and growth of uninfected children in
       their first 3 years.
 DT    9604
 AU    Ross A; Raab GM; Mok J; Gilkison S; Hamilton B; Johnstone FD; MRC
       Biostatistics Initiative for AIDS and HIV in Scotland, Centre; for HIV
       Research, Edinburgh.
 SO    Arch Dis Child. 1995 Dec;73(6):490-5. Unique Identifier : AIDSLINE
       MED/96148383
 AB    OBJECTIVE--To determine the separate effects of maternal HIV infection
       and drug use during pregnancy on growth of uninfected children in their
       first 3 years. DESIGN--Retrospective analysis of measurements from
       health visitor records made during routine child health surveillance at
       6 weeks, 10 months, and 3 years of age. Multilevel analysis allowed for
       between-infant variation in fitted growth lines, and adjustment for
       other factors. Growth was described in terms of an intercept (z score at
       term) and growth slopes (change in z score per year) up to, and from, 4
       months. SUBJECTS--290 case babies delivered in Edinburgh hospitals to
       women who reported injection drug use by either themselves or their HIV
       infected partner, and 186 community controls. A total of 131 (45%) of
       the case babies were born to women who used drugs, predominantly
       opiates, during pregnancy and 93 (32%) to HIV infected women. The eight
       infected children were excluded from analysis. MAIN OUTCOME
       MEASURES--Age and sex standardised z scores for height, weight, and body
       mass index. RESULTS--459 (96%) of the 476 records for cases and controls
       were traced, yielding 1432 weight and 939 height measurements. Maternal
       HIV infection was not found to affect growth; at 3 years the estimated
       effect on weight z score was 0.16 with 95% confidence interval (-0.25 to
       0.57) and for height 0.18 (-0.19 to 0.55). Drug use during pregnancy was
       associated with lighter babies at 40 weeks followed by depressed growth
       in the first four months, these infants remaining just slightly smaller
       at 3 years with an estimated effect on z scores of -0.5 for weight with
       95% confidence interval (-0.89 to -0.11) and -0.37 (-0.72 to -0.02) for
       height. CONCLUSIONS--Maternal HIV infection does not adversely affect
       growth in uninfected infants, and the effect of drug use during
       pregnancy is limited to small decrease in size at 3 years.
 DE    Body Height  Body Mass Index  Female  Follow-Up Studies  *Growth  Human
       *HIV Infections  Infant  Male  Pregnancy  *Pregnancy Complications,
       Infectious  *Prenatal Exposure Delayed Effects  Retrospective Studies
       *Substance Abuse  Support, Non-U.S. Gov't  Weight Gain  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

