       Document 0007
 DOCN  M9640007
 TI    Effect of comprehensive intervention program on survival of patients
       with human immunodeficiency virus infection.
 DT    9604
 AU    Laraque F; Greene A; Triano-Davis JW; Altman R; Lin-Greenberg A;
       Epidemic Intelligence Service, Centers for Disease Control and;
       Prevention, Atlanta, Ga, USA.
 SO    Arch Intern Med. 1996 Jan 22;156(2):169-76. Unique Identifier : AIDSLINE
       MED/96135998
 AB    BACKGROUND: In October 1989, an early intervention program (EIP) for
       human immunodeficiency virus (HIV) infection was initiated in New Jersey
       to provide medical care and social services to the enrollees. OBJECTIVE:
       To assess the overall effect of the EIP on the survival of HIV-infected
       patients. METHODS: Patient information collected through June 30, 1993,
       was analyzed from the Jersey City Medical Center EIP clinic. Survival
       from enrollment to death was calculated for patients who received
       follow-up at the clinic (active) and for those who only had the
       enrollment visit (inactive). The data were matched with the New Jersey
       death certificate registry. RESULTS: Of 938 patients enrolled from
       October 1989 to December 1991, 767 had T-cell subsets determined within
       3 months of enrollment: 641 patients were active and 126 were inactive.
       At entry, inactive patients had a lower median CD4+ T-cell count and
       were more likely to be symptomatic than active patients. Among the 640
       active and 125 inactive patients analyzed for survival (survivors > or =
       2 months), there were 144 (22.5%) and 48 (38.4%) deaths, respectively.
       Kaplan-Meier analysis indicated longer survival for active patients than
       for inactive patients (P < .001, Wilcoxon's test for homogeneity of
       strata); eg, survival probability at 2 years was 86% for active patients
       and 64% for inactive patients. Active patients also had longer survival
       than inactive patients when stratified by CD4+ T-cell levels or by
       clinical status. Only active and inactive patients with both CD4+ T-cell
       levels lower than 0.20 x 10(9)/L (< 200/microL) and symptoms of HIV or
       acquired immunodeficiency syndrome had similar survival rates. Survival
       was not influenced by sex, race, or HIV transmission category.
       CONCLUSION: Participation in the EIP was associated with longer survival
       of HIV-infected patients.
 DE    Adolescence  Adult  Aged  Aged, 80 and over  CD4 Lymphocyte Count
       Female  Human  HIV Infections/IMMUNOLOGY/MORTALITY/*THERAPY  Male
       Middle Age  New Jersey  Program Evaluation  Risk  Survival Analysis
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

