       Document 0002
 DOCN  M9640002
 TI    The antiinflammatory and antiviral effects of hydroxychloroquine in two
       patients with acquired immunodeficiency syndrome and active inflammatory
       arthritis.
 DT    9604
 AU    Ornstein MH; Sperber K; Division of the Rheumatology, Mount Sinai
       Medical Center, New; York, NY 10029, USA.
 SO    Arthritis Rheum. 1996 Jan;39(1):157-61. Unique Identifier : AIDSLINE
       MED/96133275
 AB    OBJECTIVE. To report the antiinflammatory and antiviral effects of
       hydroxychloroquine (HCQ) treatment in 2 patients with AIDS and
       inflammatory arthritis. METHODS. Two patients with AIDS and inflammatory
       arthritis were treated with HCQ, which was given in a loading dose of
       600 mg/day. The maintenance dosage was calculated to remain below 6.5
       mg/kg/day. Both patients had initial T cell subset studies; 1 patient,
       had serum and plasma collected before and after 1 year of HCQ treatment.
       Assays were performed for T cell subsets, recoverable human
       immunodeficiency virus type 1 (HIV-1) RNA, mitogen- and antigen-specific
       proliferation, and interleukin-6 (IL-6) levels. New studies on the use
       of HCQ as an anti-HIV-1 agent are reviewed. RESULTS. Both patients had a
       dramatic decrease in their arthritis activity. Neither patient required
       immunosuppressive therapy or developed an opportunistic infection. In
       the patient who was studied after 1 year of therapy, there was a 1-log
       decrease in recoverable HIV-1 RNA, improved mitogen- and
       antigen-specific immune responses, and a large decrease in the IL-6
       level while taking HCQ. Recent in vitro and in vivo assays in patients
       with HIV infection have shown similar antiviral and antiinflammatory
       effects from HCQ. CONCLUSION. HCQ may exert simultaneous
       anti-inflammatory and antiviral effects in patients with HIV infection
       and inflammatory arthritis. If larger studies confirm this observation,
       it may be the drug of choice in this population of patients.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DRUG THERAPY  Adult
       Anti-Inflammatory Agents/*ADMINISTRATION & DOSAGE  Antiviral
       Agents/*ADMINISTRATION & DOSAGE  Arthritis/COMPLICATIONS/*DRUG
       THERAPY/RADIOGRAPHY  Arthritis, Rheumatoid/COMPLICATIONS/DRUG
       THERAPY/RADIOGRAPHY  Case Report  Female  Human
       Hydroxychloroquine/*ADMINISTRATION & DOSAGE  Male  Middle Age  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

