       Document 0737
 DOCN  M9630737
 TI    Cytomegalovirus retinitis in AIDS: natural history, diagnosis, and
       treatment.
 DT    9603
 AU    Dunn JP; Jabs DA; Johns Hopkins University School of Medicine,
       Baltimore, Maryland,; USA.
 SO    AIDS Clin Rev. 1995-96;:99-129. Unique Identifier : AIDSLINE
       MED/96089199
 AB    Cytomegalovirus retinitis is the most common intraocular infection and
       the leading cause of blindness in patients with AIDS. Diagnosis is made
       on clinical grounds; a variety of other infectious and neoplastic
       retinitides should be considered in the differential diagnosis.
       Treatment with intravenous ganciclovir or foscarnet has been proven
       effective, but late complications of relapse, viral resistance, retinal
       detachment, and drug toxicity remain problematic. Approved and
       investigational drugs for the treatment of CMV retinitis are limited by
       their virostatic, rather than virocidal, properties. Because the
       efficacies of ganciclovir and foscarnet are similar, the choice of
       therapy should be based on systemic considerations such as drug toxicity
       and patient survival. The cost, toxicity, and limited efficacy of
       currently available therapy of CMV retinitis make the need for an
       effective prophylactic drug even more important.
 DE    AIDS-Related Opportunistic Infections/DIAGNOSIS/*DRUG THERAPY
       Cytomegalovirus Infections/DIAGNOSIS/*DRUG THERAPY  Human  Retinal
       Detachment/ETIOLOGY  Retinitis/COMPLICATIONS/DIAGNOSIS/*DRUG THERAPY
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

