       Document 0717
 DOCN  M9630717
 TI    Genetic control of the CD4/CD8 T-cell ratio in humans [see comments]
 DT    9603
 AU    Amadori A; Zamarchi R; De Silvestro G; Forza G; Cavatton G; Danieli GA;
       Clementi M; Chieco-Bianchi L; Institute of Oncology, Interuniversity
       Center for Research on; Cancer, University of Padova, Italy.
 SO    Nat Med. 1995 Dec;1(12):1279-83. Unique Identifier : AIDSLINE
       MED/96083628
 CM    Comment in: Nat Med 1995 Dec;1(12):1240-1
 AB    We studied the genetic pattern of inheritance of the ratio between
       circulating CD4+ and CD8+ T lymphocytes in a population of healthy
       donors. The distribution of the CD4/CD8 ratio in males and females was
       significantly different and was significantly affected by age. In 46
       randomly selected families, the parental CD4/CD8 ratio significantly
       influenced the ratio in offspring. Complex segregation analysis of the
       data rejected the non-genetic hypothesis; among the genetic models
       tested, a major recessive gene with a polygenic component and random
       environmental effects was the most parsimonious model. These findings
       indicate that the ratio of CD4+ and CD8+ T cells is genetically
       controlled in humans.
 DE    Adult  Age Factors  *CD4-CD8 Ratio  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY/ULTRASTRUCTURE  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY/ULTRASTRUCTURE  Female  Genes, Recessive
       Genetics, Population  Human  Italy  Male  Models, Genetic  *Phenotype
       Sex Factors  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

