       Document 0709
 DOCN  M9630709
 TI    A sonographic-pathological correlation of liver biopsies in patients
       with the acquired immune deficiency syndrome (AIDS).
 DT    9603
 AU    Beale TJ; Wetton CW; Crofton ME; Department of Radiology, St Mary's
       Hospital, London, UK.
 SO    Clin Radiol. 1995 Nov;50(11):761-4. Unique Identifier : AIDSLINE
       MED/96080102
 AB    The liver is commonly involved in patients with AIDS and a first line
       investigation for hepatic dysfunction is liver ultrasound (US) which is
       often abnormal. It is unclear how these US abnormalities correlate with
       the underlying pathological processes. A retrospective study was
       performed in 48 patients with HIV disease who had undergone both liver
       biopsy and hepatic (US), correlating the findings. Only 25% of patients
       had an entirely normal liver (US) examination and only 10% patients had
       a normal liver biopsy. The commonest sonographic abnormalities was a
       diffusely hyperechoic liver seen in 46% of patients and this correlated
       with steatosis. Forty-four percent of biopsies contained more than one
       histological abnormality including granulomas, inflammation, steatosis
       or siderosis. In addition clinically unsuspected pathology was revealed
       in five of the cases of mycobacterial infection and in three cases of
       lymphoma. The combination of multiple histological abnormalities,
       unsuspected pathology, and the altered immune response in this group
       makes the US findings even less specific than in non-AIDS patients. We
       recommend that liver biopsy should remain an essential and early part of
       the management of AIDS patients.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY/*ULTRASONOGRAPHY  Adult
       Aged  AIDS-Related Opportunistic Infections/COMPLICATIONS  Biopsy,
       Needle  Female  Human  Liver/*PATHOLOGY  Liver
       Diseases/*PATHOLOGY/*ULTRASONOGRAPHY  Male  Middle Age  Mycobacterium
       Infections/COMPLICATIONS  Retrospective Studies  Sensitivity and
       Specificity  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

