       Document 0696
 DOCN  M9630696
 TI    Drug induced acute pancreatitis: incidence and severity.
 DT    9603
 AU    Lankisch PG; Droge M; Gottesleben F; Department of Internal Medicine,
       Municipal Hospital of Luneburg,; Germany.
 SO    Gut. 1995 Oct;37(4):565-7. Unique Identifier : AIDSLINE MED/96097888
 AB    To determine the incidence and severity of drug induced acute
       pancreatitis, data from 45 German centres of gastroenterology were
       evaluated. Among 1613 patients treated for acute pancreatitis in 1993,
       drug induced acute pancreatitis was diagnosed in 22 patients (incidence
       1.4%). Drugs held responsible were azathioprine,
       mesalazine/sulfasalazine, 2',3'-dideoxyinosine (ddI), oestrogens,
       frusemide, hydrochlorothiazide, and rifampicin. Pancreatic necrosis not
       exceeding 33% of the organ was found on ultrasonography or computed
       tomography, or both, in three patients (14%). Pancreatic pseudocysts did
       not occur. A decrease of arterial PO2 reflecting respiratory
       insufficiency, and an increase of serum creatinine, reflecting renal
       insufficiency as complications of acute pancreatitis were seen in two
       (9%) and four (18%) patients, respectively. Artificial ventilation was
       not needed, and dialysis was necessary in only one (5%) case. Two
       patients (9%) died of AIDS and tuberculosis, respectively; pancreatitis
       did not seem to have contributed materially to their death. In
       conclusion, drugs rarely cause acute pancreatitis, and drug induced
       acute pancreatitis usually runs a benign course.
 DE    Acute Disease  Adult  Aged  Aged, 80 and over  Azathioprine/ADVERSE
       EFFECTS  Didanosine/ADVERSE EFFECTS  Estrogens/ADVERSE EFFECTS  Female
       Furosemide/ADVERSE EFFECTS  Germany/EPIDEMIOLOGY  Human
       Hydrochlorothiazide/ADVERSE EFFECTS  Incidence  Length of Stay  Male
       Middle Age  Pancreatitis/*CHEMICALLY INDUCED/EPIDEMIOLOGY
       Rifampin/ADVERSE EFFECTS  Sulfasalazine/ADVERSE EFFECTS  JOURNAL ARTICLE
       MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

