       Document 0668
 DOCN  M9630668
 TI    Two-step development of Hashimoto-like thyroiditis in genetically
       autoimmune prone non-obese diabetic mice: effects of iodine-induced cell
       necrosis.
 DT    9603
 AU    Many MC; Maniratunga S; Varis I; Dardenne M; Drexhage HA; Denef JF;
       Laboratory of Histology, Catholic University of Louvain, Medical;
       School, Brussels, Belgium.
 SO    J Endocrinol. 1995 Nov;147(2):311-20. Unique Identifier : AIDSLINE
       MED/96096304
 AB    The administration of a high iodide dose (HID; 10 micrograms/day) to
       goitrous mice is known to induce thyroid cell necrosis and inflammation,
       which, in most strains, is transient. In this study, we analyzed the
       effects of iodide in autoimmune prone non-obese diabetic (NOD) mice.
       Control NOD mice fed a standard diet (MID; 1 microgram I/day) or HID did
       not spontaneously develop thyroiditis. In NOD mice previously made
       goitrous, HID provoked thyroid cell necrosis and diffuse inflammation
       within 4 days. Inflammatory cells consisted of MHC-class II+
       antigen-presenting cells, CD4+ T helper cells and CD8+ T
       suppressor/cytotoxic cells. After 96 days of treatment with HID,
       thyroiditis similar to Hashimoto's disease was obtained in 100% of the
       animals, with destruction of thyroid follicles, large clusters of T and
       B cells, and antithyroid antibodies in the plasma. When treating
       goitrous mice with MID, no cell necrosis was observed and no autoimmune
       thyroiditis was obtained. The early iodide-induced cell necrosis and
       inflammation may thus be considered as an important factor in the
       induction and persistence of autoimmune thyroiditis in individuals
       carrying a genetic susceptibility to autoimmune disease.
 DE    Animal  Antigen-Presenting Cells/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Disease
       Susceptibility  Female  Fluorescent Antibody Technique, Indirect
       Goiter/IMMUNOLOGY  Histocompatibility Antigens Class II/IMMUNOLOGY
       Immunohistochemistry  Inflammation  Iodides/ADMINISTRATION &
       DOSAGE/*ADVERSE EFFECTS  Mice  Mice, Inbred NOD/*IMMUNOLOGY  Necrosis
       Support, Non-U.S. Gov't  Thyroid Gland/*DRUG
       EFFECTS/IMMUNOLOGY/PATHOLOGY  Thyroiditis, Autoimmune/*CHEMICALLY
       INDUCED/GENETICS/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

