       Document 0667
 DOCN  M9630667
 TI    Prolactin receptor expression in lymphocytes from patients with
       hyperprolactinemia or acromegaly.
 DT    9603
 AU    Leite-de-Moraes MC; Touraine P; Kelly PA; Kuttenn F; Dardenne M;
       Universite Rene Descartes, Paris V, CNRS URA 1461, Hopital; Necker,
       Paris, France.
 SO    J Endocrinol. 1995 Nov;147(2):353-9. Unique Identifier : AIDSLINE
       MED/96096308
 AB    Previous reports demonstrated that prolactin receptors (PRL-R) are
       widely expressed on cells of the immune system. We analyzed a possible
       regulation of PRL-R expression on human mononucleated blood cells by
       prolactin (PRL) itself. PRL-R expression was analyzed by
       immunofluorescence on T and B lymphocytes and monocytes from peripheral
       blood mononucleated cells (PBMC) of patients with hyperprolactinemia or
       acromegaly compared with sex- and age-matched control subjects. The
       frequency of PRL-R positive cells and the intensity of PRL-R expression
       was only modified among the CD8+ T cell population of hyperprolactinemic
       patients with macroadenoma. No correlation was reported between PRL-R
       expression and circulating PRL levels. The percentage of PRL-R+ cells on
       B or T lymphocytes and monocytes as well as the capacity of PBMC to
       proliferate in response to T cell mitogens were not significantly
       different in bromocriptine-treated compared with untreated patients.
       These findings suggest that factors other than pituitary PRL play the
       major role in regulating PRL-R expression on cells of the immune system.
 DE    Acromegaly/DRUG THERAPY/*METABOLISM  Adenoma/IMMUNOLOGY/METABOLISM
       Adult  Bromocriptine/THERAPEUTIC USE  Cells, Cultured  CD8-Positive
       T-Lymphocytes/METABOLISM/PATHOLOGY  Down-Regulation (Physiology)  Flow
       Cytometry  Human  Hyperprolactinemia/DRUG THERAPY/IMMUNOLOGY/*METABOLISM
       Lymphocyte Count  Lymphocytes/*METABOLISM  Middle Age  Pituitary
       Neoplasms/IMMUNOLOGY/METABOLISM  Receptors, Prolactin/DRUG
       EFFECTS/*METABOLISM  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

