       Document 0665
 DOCN  M9630665
 TI    A controlled study of anxiety and morbid cognitions at initial screening
       for human immunodeficiency virus (HIV) in a cohort of people with
       haemophilia.
 DT    9603
 AU    Jones QJ; Garsia RJ; Wu RT; Job RF; Dunn SM; Medical Psychology Unit,
       University of Sydney, Australia.
 SO    J Psychosom Res. 1995 Jul;39(5):597-608. Unique Identifier : AIDSLINE
       MED/96058809
 AB    AIM. This study examines the relationship between anxiety, psychological
       state and Human Immunodeficiency Virus (HIV) stages as defined by the
       Centers for Disease Control at the time of initial screening for HIV in
       a cohort of people with haemophilia who were at risk of prior exposure
       to HIV transmission from blood products. METHOD. Psychological scores,
       immunological measures, and clinical data from case notes for 116
       potentially HIV exposed people with haemophilia attending initial
       screening for HIV infection in 1984-1985, were used to examine the
       relationship between psychological variables, clinical state and their
       clinical classification under the Centres for Disease Control
       categorization. Psychometric test results were obtained for 63 HIV
       seronegative patients and 53 HIV seropositive patients. Planned
       comparisons, multiple and logistic regressions, were used to explain
       observed differences between seronegative and seropositive subjects. The
       potential confounders of sex, age, severity of haemophilia, haemophilia
       type and blood product usage were controlled. RESULTS. The major finding
       of this study was that higher levels of State Anxiety at the time of
       initial screening for HIV, were observed in those patients who lacked
       recognized symptoms of HIV infection and were seropositive, compared
       with seronegative subjects. The State Anxiety scores were predicted by
       HIV infection or alternatively CD4+ T-cell levels. CONCLUSION. The
       findings of this study suggest that HIV infection can produce
       psychological effects prior to any physical symptoms of infection being
       apparent.
 DE    von Willebrand's Disease/*PSYCHOLOGY  Adult  Anxiety/*PSYCHOLOGY
       *Attitude to Health  AIDS Serodiagnosis/*PSYCHOLOGY  Blood Component
       Transfusion/PSYCHOLOGY  Christmas Disease/*PSYCHOLOGY  Female
       Hemophilia/*PSYCHOLOGY  Human  HIV Infections/*PSYCHOLOGY/TRANSMISSION
       HIV Seronegativity  HIV Seropositivity/PSYCHOLOGY  Male  Mass
       Screening/*PSYCHOLOGY  Risk Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

