       Document 0635
 DOCN  M9630635
 TI    The effects of HIV on cognitive and motor development in children born
       to HIV-seropositive women with no reported drug use: birth to 24 months.
 DT    9603
 AU    Gay CL; Armstrong FD; Cohen D; Lai S; Hardy MD; Swales TP; Morrow CJ;
       Scott GB; Department of Pediatrics, University of Miami School of
       Medicine,; FL 33101, USA.
 SO    Pediatrics. 1995 Dec;96(6):1078-82. Unique Identifier : AIDSLINE
       MED/96095157
 AB    OBJECTIVE. This study documents delays in the mental and motor
       functioning of infants perinatally infected with human immunodeficiency
       virus (HIV) while controlling for confounding effects of prenatal drug
       exposure, ethnicity, socioeconomic status, and maternal separation and
       death. METHODS. The cognitive and motor development of 126 infants born
       to nondrug-using, HIV-seropositive Haitian women was assessed at 3-month
       intervals through 24 months of age using the Bayley Scales of Infant
       Development. By 18 months of age, 28 of the infants were diagnosed as
       HIV-infected, and the 98 uninfected infants served as a control group.
       The infected and uninfected infants did not differ with respect to mean
       gestational age, birth weight, ethnicity, or rates of maternal
       separation and death. RESULTS. By 3 months of age, the mean mental and
       motor scores of the infected infants were significantly lower than those
       of the uninfected controls. Furthermore, the initial differences between
       the two groups increased over time, as many of the infected infants
       became increasingly delayed. Although the infected infants tended to
       perform more poorly than the uninfected infants, nearly one third of the
       infected infants exhibited relatively normal cognitive development and
       half demonstrated relatively normal motor development. CONCLUSIONS. Over
       the first 24 months of life, the mean rate of development of
       HIV-infected infants is significantly slower than that of noninfected
       infants born to seropositive mothers. This occurs even when the effects
       are not confounded with those of prenatal drug exposure.
 DE    Adult  *Child Development  Child, Preschool  *Cognition  Comparative
       Study  Female  Florida  Haiti/ETHNOLOGY  Human  HIV
       Infections/*PSYCHOLOGY  HIV Seropositivity/*PSYCHOLOGY
       HIV-1/*IMMUNOLOGY  Infant  Infant, Newborn  Male  Psychological
       Tests/STATISTICS & NUMER DATA  *Psychomotor Performance  Substance Abuse
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

