       Document 0620
 DOCN  M9630620
 TI    Replication of molluscum contagiosum virus.
 DT    9603
 AU    Buller RM; Burnett J; Chen W; Kreider J; Laboratory of Viral Diseases,
       National Institute of Allergy and; Infectious Diseases, National
       Institutes of Health, Bethesda,; Maryland 20892, USA.
 SO    Virology. 1995 Nov 10;213(2):655-9. Unique Identifier : AIDSLINE
       MED/96074540
 AB    Molluscum contagiosum virus (MCV) infects preadolescent children and
       sexually active adults, frequently causing a disfiguring cutaneous
       disease in immunosuppressed HIV-infected individuals. The development of
       an efficacious treatment regime has been hampered by the failure to
       replicate the virus in the laboratory. Here we report the first
       demonstration of MCV replication in an experimental system. In human
       foreskin grafts to athymic mice, MCV induced morphological changes which
       were indistinguishable from patient biopsies and included the
       development and migration of molluscum bodies containing mature virions
       to the epidermal surface.
 DE    Animal  DNA, Viral/*ANALYSIS  Human  Infant, Newborn  Male  Mice  Mice,
       Nude  Molluscum Contagiosum/PATHOLOGY/*VIROLOGY  Molluscum Contagiosum
       Virus/ISOLATION & PURIF/*PHYSIOLOGY  Skin/PATHOLOGY/*VIROLOGY  Skin
       Transplantation  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Transplantation, Heterologous  Virion/METABOLISM  Virus Replication
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

