       Document 0615
 DOCN  M9630615
 TI    Hepatotoxicity of antibiotics.
 DT    9603
 AU    Hautekeete ML; Department of Hepato-Gastroenterology, Free University
       of; Brussels (AZ-VUB), Belgium.
 SO    Acta Gastroenterol Belg. 1995 May-Aug;58(3-4):290-6. Unique Identifier :
       AIDSLINE MED/96076758
 AB    Several antibiotics can cause severe hepatic injury. It is the purpose
       of this paper to review the main antibiotics that can cause hepatic
       injury and discuss the presentation, pattern, and outcome of hepatic
       injury. In the case of the penicillins, the combination
       amoxycillin-clavulanate and the penicillinase-resistant penicillins
       oxacillin, (di-)cloxacillin, and flucloxacillin can cause (mainly
       cholestatic) hepatitis. Cephalosporins have little hepatotoxicity;
       ceftriaxone can cause drug-induced gallstones. The potential of
       erythromycin and several other macrolides to cause (usually cholestatic)
       hepatitis is well established. Tetracyclines can cause a syndrome
       mimicking acute fatty liver of pregnancy, but this complication has
       virtually disappeared. Quinolones seem to be able to cause cholestasis.
       Sulfamethoxazole/trimethoprim can cause severe hepatotoxicity,
       especially in patients with acquired immunodeficiency syndrome (AIDS).
       Finally, nitrofurantoin can cause acute cholestatic and hepatocellular
       reactions as well as chronic hepatitis mimicking chronic auto-immune
       hepatitis.
 DE    Adult  Anti-Infective Agents, Quinolone/TOXICITY  Antibiotics/*TOXICITY
       Antibiotics, Macrolide/TOXICITY  Cephalosporins/TOXICITY  Child  Female
       Hepatitis, Toxic/*ETIOLOGY  Human  Liver/*DRUG EFFECTS  Male
       Nitrofurantoin/TOXICITY  Penicillins/TOXICITY  Pregnancy
       Tetracyclines/TOXICITY  Trimethoprim-Sulfamethoxazole
       Combination/TOXICITY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

