       Document 0614
 DOCN  M9630614
 TI    Long-chain polyunsaturated fatty acids in children with severe
       protein-energy malnutrition with and without human immunodeficiency
       virus-1 infection.
 DT    9603
 AU    Decsi T; Zaknun D; Zaknun J; Sperl W; Koletzko B; Kinderpoliklinik,
       Ludwig-Maximilians-University, Munich, Germany.
 SO    Am J Clin Nutr. 1995 Dec;62(6):1283-8. Unique Identifier : AIDSLINE
       MED/96094678
 AB    Fatty acids in plasma phospholipids were studied in 35 severely
       malnourished young children with a median age of 29 mo (range: 9-43 mo),
       who were either seronegative for human immunodeficiency virus-1 (HIV) (n
       = 16) or suffered from asymptomatic (stage P-1; n = 12) or symptomatic
       (stage P-2; n = 7) HIV disease. The malnourished children had
       significantly lower percentages (% by wt) of phospholipid arachidonic
       (20:4n-6, AA) and docosahexaenoic (22:6n-3, DHA) acids than 25
       age-matched healthy control subjects (AA: 7.05% and 8.70% by wt; DHA:
       0.92 and 2.61% by wt, P < 0.001). Body weights of malnourished children
       did not correlate with linoleic (18:2n-6) and alpha-linolenic (18:3n-3)
       acid values but were significantly and positively correlated with AA and
       DHA values (r = 0.40, P = 0.02 and r = 0.63, P < 0.0001, respectively).
       Plasma concentrations (mg/L) of total phospholipid fatty acids did not
       differ among seronegative, stage P-1, or stage P-2 patients. Percentage
       contributions of AA and eicosapentaenoic acid (20:5n-3, EPA) did not
       differ among those seronegative or in stages P-1 and P-2. In contrast,
       values of dihomo-gamma-linolenic acid (20:3n-6) were significantly (P <
       0.05) lower in stage P-2 (2.38 mg/L) than in either seronegative (3.47
       mg/L) or stage P-1 (3.66 mg/L) patients. We conclude that the severely
       malnourished children developed a depletion of both AA and DHA
       proportional to the degree of malnutrition.(ABSTRACT TRUNCATED AT 250
       WORDS)
 DE    Arachidonic Acids/BLOOD  Body Weight/PHYSIOLOGY  Child, Preschool
       Comparative Study  Docosahexaenoic Acids/BLOOD  Fatty Acids,
       Unsaturated/*BLOOD/METABOLISM  Human  HIV
       Infections/*BLOOD/COMPLICATIONS/PHYSIOPATHOLOGY  *HIV-1  Infant
       Linoleic Acids/BLOOD  Phospholipids/BLOOD  Protein-Energy
       Malnutrition/*BLOOD/COMPLICATIONS/PHYSIOPATHOLOGY  Support, Non-U.S.
       Gov't  5,8,11,14,17-Eicosapentaenoic Acid/BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

