       Document 0610
 DOCN  M9630610
 TI    Analysis of mutations at position 184 in reverse transcriptase of human
       immunodeficiency virus type 1.
 DT    9603
 AU    Boyer PL; Hughes SH; Advanced BioScience Laboratories-Basic Research
       Program, National; Cancer Institute-Frederick Cancer Research and
       Development; Center, Maryland 21702-1201, USA.
 SO    Antimicrob Agents Chemother. 1995 Jul;39(7):1624-8. Unique Identifier :
       AIDSLINE MED/96104915
 AB    We have analyzed recombinant human immunodeficiency virus type 1 reverse
       transcriptases that contain mutations at position 184. These variants
       retain high levels of RNA-dependent DNA polymerase activity and show
       resistance to ddITP. However, the mutants varied in their ability to
       polymerize processively. The variants Met184Ile and Met184Val showed
       slight reductions in processivity relative to that of the wild-type
       enzyme; the variants Met184Ala and Met184Leu showed considerable
       reductions in their processivity.
 DE    Base Sequence  Binding Sites  DNA Mutational Analysis  DNA
       Polymerases/GENETICS/METABOLISM  Escherichia coli/GENETICS/METABOLISM
       Molecular Sequence Data  Mutagenesis, Insertional  *Mutation
       Recombinant Proteins/GENETICS/METABOLISM  RNA-Directed DNA
       Polymerase/*GENETICS/METABOLISM  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

