       Document 0604
 DOCN  M9630604
 TI    A comparison of cerebral SPECT abnormalities in HIV-positive homosexual
       men with and without cognitive impairment.
 DT    9603
 AU    Sacktor N; Van Heertum RL; Dooneief G; Gorman J; Khandji A; Marder K;
       Nour R; Todak G; Stern Y; Mayeux R; Gertrude H. Sergievsky Center,
       Columbia University College of; Physicians and Surgeons, New York, NY,
       USA.
 SO    Arch Neurol. 1995 Dec;52(12):1170-3. Unique Identifier : AIDSLINE
       MED/96094927
 AB    OBJECTIVE: To determine whether technetium Tc 99m exametazime (HMPAO)
       single-photon emission computed tomography (SPECT) can distinguish
       between human immunodeficiency virus (HIV)-positive homosexual men with
       normal neuropsychologic test results and HIV-positive homosexual men
       with abnormal neuropsychologic test results. DESIGN: Neurologic,
       neuropsychologic, magnetic resonance imaging, and Tc 99m HMPAO SPECT
       examinations were performed on 10 HIV-positive homosexual men without
       cognitive impairment and five HIV-positive homosexual men with cognitive
       impairment. PATIENTS: Human immunodeficiency virus-positive homosexual
       men from New York City were recruited for the study. MAIN OUTCOME
       MEASURES: Findings on SPECT scans were evaluated qualitatively for focal
       defects, heterogeneity of the cortical margin, white matter
       hypoperfusion, and decreased global cortical uptake. All SPECT focal
       defects were coregistered with magnetic resonance images; SPECT
       heterogeneity and global cortical uptake were also measured
       quantitatively. RESULTS: Coregistration with magnetic resonance imaging
       revealed that 63% of the focal SPECT defects corresponded to brain gyri
       and 37% corresponded to sulci. There was no significant difference in
       the frequency of qualitative or quantitative SPECT abnormalities between
       HIV-positive homosexual men ith and without cognitive impairment.
       However, after examining individual neuropsychologic test factors,
       impaired motor speed performance was associated with decreased
       quantitative global cerebral uptake. CONCLUSIONS: Qualitative SPECT
       abnormalities are not increased in frequency in HIV-positive homosexual
       men with global cognitive impairment compared with those in HIV-positive
       homosexual men without cognitive impairment. Impaired motor speed
       performance may be associated with decreased quantitative global
       cerebral uptake.
 DE    Adult  Brain/PATHOLOGY/*RADIONUCLIDE IMAGING  Cognition
       Disorders/DIAGNOSIS/ETIOLOGY/*RADIONUCLIDE IMAGING  Comparative Study
       *Homosexuality, Male  Human  HIV
       Infections/*COMPLICATIONS/PSYCHOLOGY/RADIONUCLIDE IMAGING  Linear Models
       Magnetic Resonance Imaging  Male  Middle Age  Neuropsychological Tests
       Organotechnetium Compounds/DIAGNOSTIC USE  Oximes/DIAGNOSTIC USE
       Psychomotor Performance  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  Tomography, Emission-Computed, Single-Photon  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

