       Document 0585
 DOCN  M9630585
 TI    A new HTLV type II subtype A isolate in an HIV type 1-infected
       prostitute from Cameroon, Central Africa.
 DT    9603
 AU    Mauclere P; Mahieux R; Garcia-Calleja JM; Salla R; Tekaia F; Millan J;
       De The G; Gessain A; Centre Pasteur du Cameroun, Yaounde.
 SO    AIDS Res Hum Retroviruses. 1995 Aug;11(8):989-93. Unique Identifier :
       AIDSLINE GENBANK/Z46837
 AB    Among 332 female sex workers in Douala, Cameroon, 113 were HIV-1
       seropositive, 3 were HTLV-I seropositive, and only 1 had specific
       anti-HTLV-II antibodies. By cocultivation with BJAB cells, an HTLV-II
       was isolated from the peripheral blood mononuclear cells of this
       32-year-old woman coinfected by HIV-1. This new African HTLV-II isolate
       (PH230PCAM) belongs to the molecular subtype A, exhibiting, however, a
       nucleotide variability of 2.4% and 0.8%, vis-a-vis the MO prototype, in
       the LTR and in the gp21 env gene, respectively. These data, as well as
       the previous findings of another HTLV-II subtype A in a Ghanean
       prostitute, suggest that this viral subtype had been imported into
       Africa, while the HTLV-II subtype B, described in remote areas of Zaire,
       Gabon, and Cameroon, could be a genuine African HTLV-II, present in this
       continent for a long period of time.
 DE    Adult  Base Sequence  Cameroon  Case Report  Female  Human  HIV
       Infections/*COMPLICATIONS  HIV-1/*ISOLATION & PURIF
       HTLV-II/GENETICS/*ISOLATION & PURIF  HTLV-II
       Infections/COMPLICATIONS/*VIROLOGY  Molecular Sequence Data
       Prostitution  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

