       Document 0577
 DOCN  M9630577
 TI    Effect of administration of serum thymic factor (FTS) in calves and
       rabbits infected with bovine immunodeficiency-like virus.
 DT    9603
 AU    Hirai N; Furuyama H; Awaya A; Onuma M; Department of Epizootiology,
       Faculty of Veterinary Medicine,; Hokkaido University, Japan.
 SO    J Vet Med Sci. 1995 Apr;57(2):307-10. Unique Identifier : AIDSLINE
       MED/96114695
 AB    The effect of serum thymic factor (FTS) administration in bovine
       immunodeficiency-like virus (BIV)-infected calves and rabbits was
       examined. We previously found that some of the macrophage functions were
       depressed and humoral immune responses against foreign proteins were
       delayed in BIV-infected calves compared to uninfected calves. After FTS
       administration, however, no delay of antibody responses against foreign
       proteins was observed in BIV-infected calves. Though the
       chemiluminescence (CL) responses of macrophages in BIV-infected calves
       were significantly depressed (p < 0.05), FTS administration resulted in
       the recovery of the CL responses in the BIV-infected calves comparable
       to those in the control calves. Antibody responses against foreign
       proteins in BIV-infected rabbits were significantly depressed (p <
       0.025) as compared with those in uninfected rabbits, though the
       depression became no significant after FTS administration.
 DE    Animal  Antibody Formation  Blood Proteins/IMMUNOLOGY  Cattle
       Chemiluminescence  Erythrocytes/IMMUNOLOGY  *Immunodeficiency Virus,
       Bovine  Lentivirus Infections/*IMMUNOLOGY/THERAPY
       Macrophages/*IMMUNOLOGY  Mice  Rabbits  Sheep  Thymic Factor,
       Circulating/*PHARMACOLOGY  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

