       Document 0566
 DOCN  M9630566
 TI    Human immunodeficiency virus-related microvasculopathy and Kaposi's
       sarcoma: a case-control study.
 DT    9603
 AU    Baumann S; Geier SA; Thoma-Gerber E; Noehl MA; Klauss V; Goebel FD;
       University Eye Hospital Munich, Germany.
 SO    Ger J Ophthalmol. 1995 Jul;4(4):239-45. Unique Identifier : AIDSLINE
       MED/96115075
 AB    Ocular microangiopathic syndrome including retinal and conjunctival
       abnormalities is frequently found in patients with human
       immunodeficiency virus type 1 (HIV-1) disease. Kaposi's sarcoma (KS) is
       the most frequent neoplasia found in patients with HIV-1 disease. We
       have recently reported a significant association between conjunctival
       microvasculopathy and KS in 117 patients with HIV-1 disease. The
       objective of the present study was to determine whether this association
       is existent when matched patients with and without KS are compared. A
       total of 22 matched pairs were obtained under consideration of the
       absolute CD4+ lymphocyte count, Walter Reed (WR) classification, gender,
       and serum levels of beta-2-microglobulin and neopterin. Conjunctival
       microangiopathy was determined for each eye by a standardized rating
       scale ranging from 0 to 5, allowing a reliable and valid quantification
       of conjunctival blood-flow sludging. The mean value obtained for
       conjunctival sludge was 1.8 (SEM, 0.4) for patients without KS and 3.2
       (SEM, 0.3) for patients with KS, demonstrating a clinically and
       statistically significant difference between the two groups (Student's t
       = 3.0; P = 0.003). This difference was higher when patients with a CD4+
       lymphocyte count exceeding 200/microliters were regarded. Similar
       factors or mechanisms may contribute to HIV-related conjunctival
       microvasculopathy and KS.
 DE    beta 2-Microglobulin/ANALYSIS  Adult  Biopterin/ANALOGS &
       DERIVATIVES/BLOOD  Case-Control Studies  Conjunctiva/*BLOOD SUPPLY
       Conjunctival Diseases/BLOOD/*COMPLICATIONS/PHYSIOPATHOLOGY  CD4
       Lymphocyte Count  Female  Human  HIV Infections/BLOOD/*COMPLICATIONS
       *HIV-1  Male  Microcirculation  Middle Age  Sarcoma,
       Kaposi's/BLOOD/*COMPLICATIONS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

