       Document 0539
 DOCN  M9630539
 TI    Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from
       fruits of Gleditsia japonica and Gymnocladus chinensis, and a
       structure-activity correlation.
 DT    9603
 AU    Konoshima T; Yasuda I; Kashiwada Y; Cosentino LM; Lee KH; Kyoto
       Pharmaceutical University, Japan.
 SO    J Nat Prod. 1995 Sep;58(9):1372-7. Unique Identifier : AIDSLINE
       MED/96043281
 AB    Gleditsia saponin C [1] and gymnocladus saponin G [2] were isolated from
       Gleditsia japonica and Gymnocladus chinensis, respectively, as anti-HIV
       principles. Compounds 1 and 2 demonstrated inhibitory effects against
       HIV replication in H-9 cells with EC50 values of 1.1 and 2.7 microM,
       respectively. Evaluation of the anti-HIV activities of the prosapogenins
       of 1 and 2 suggested that the unusual monoterpenyl moieties in 1 and 2
       are essential for their anti-HIV activity. Derivatives of echinocystic
       acid [8], the aglycone of compound 1, were also prepared and evaluated
       for inhibitory activity against HIV replication.
       3,16-Di-O-acetylechinocystic acid [12] was shown to be an anti-HIV agent
       with an EC50 value of 2.3 microM.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY  Antiviral
       Agents/CHEMISTRY/CHEMICAL SYNTHESIS/*PHARMACOLOGY  Carbohydrate Sequence
       Human  HIV-1/*DRUG EFFECTS/PHYSIOLOGY  In Vitro  Molecular Sequence Data
       Plants, Medicinal/*CHEMISTRY  Saponins/CHEMISTRY/CHEMICAL
       SYNTHESIS/*PHARMACOLOGY  Structure-Activity Relationship  Support, U.S.
       Gov't, P.H.S.  Terpenes/CHEMISTRY/CHEMICAL SYNTHESIS/PHARMACOLOGY  Virus
       Replication/DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

