       Document 0538
 DOCN  M9630538
 TI    Immunohistochemical study of linear gingival erythema from HIV-positive
       patients.
 DT    9603
 AU    Gomez RS; da Costa JE; Loyola AM; de Araujo NS; de Araujo VC;
       Departamento de Clinica, Patologia e Cirurgia da Faculdade de;
       Odontologia da Universidade Federal de Minas Gerais, Belo; Horizonte,
       Brasil.
 SO    J Periodontal Res. 1995 Sep;30(5):355-9. Unique Identifier : AIDSLINE
       MED/96098579
 AB    Severe forms of periodontal disease are frequent in patients with
       acquired immunodeficiency syndrome (AIDS). Linear gingival erythema
       (LGE) is a progressive disease described in HIV-positive patients and is
       considered to be an early stage of necrotizing periodontitis. Although
       clinical and microbiological differences are reported in LGE and
       non-specific gingivitis (NSG), a comparative immunopathological approach
       of both has not been performed yet. The purpose of this study was to
       compare relative populations of T-lymphocytes, B-lymphocytes,
       neutrophils, macrophages and IgG bearing plasma cells in gingival
       biopsies from sites exhibiting LGE and from sites exhibiting NSG. A
       biotin-streptavidin amplified system was used for identification of the
       following antigens: CD3 (T-lymphocytes), CD20 (B-lymphocytes), elastase
       (neutrophils), CD68 (macrophages) and IgG (plasma cell's secretors of
       IgG). The results have demonstrated decrease proportions of
       T-lymphocytes, macrophages and high percentage of neutrophils and IgG
       bearing plasma cells in LGE. In contrast with NSG, many neutrophils
       cells in LGE were found inside oral gingival epithelium. Our results
       highlight the idea that progressive periodontal disease is not only
       characterized by increased tissue inflammation, but, in addition, by
       significant changes in the proportion of specific inflammatory cells.
       The high number of neutrophils along the gingival epithelium is probably
       associated with the severe gingival necrosis reported in AIDS patients.
 DE    Adult  Animal  Antibodies, Monoclonal  Antigens, CD  Antigens, CD20
       Antigens, CD3  Antigens, Differentiation, Myelomonocytic
       B-Lymphocytes/IMMUNOLOGY  Erythema/ENZYMOLOGY/*ETIOLOGY/IMMUNOLOGY
       Female  Gingival Diseases/ENZYMOLOGY/*ETIOLOGY/*IMMUNOLOGY
       Gingivitis/ETIOLOGY/IMMUNOLOGY  Gingivitis, Necrotizing
       Ulcerative/ENZYMOLOGY/ETIOLOGY/IMMUNOLOGY  Human  HIV
       Infections/*COMPLICATIONS  IgG  Immunoenzyme Techniques  Leukocyte Count
       Macrophages/IMMUNOLOGY  Male  Mice  Middle Age
       Neutrophils/ENZYMOLOGY/IMMUNOLOGY  Pancreatopeptidase/ANALYSIS  Plasma
       Cells/IMMUNOLOGY  Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

