       Document 0526
 DOCN  M9630526
 TI    Distribution of baboon endogenous virus among species of African monkeys
       suggests multiple ancient cross-species transmissions in shared
       habitats.
 DT    9603
 AU    van der Kuyl AC; Dekker JT; Goudsmit J; Human Retrovirus Laboratory,
       Academic Medical Centre, Amsterdam,; The Netherlands.
 SO    J Virol. 1995 Dec;69(12):7877-87. Unique Identifier : AIDSLINE
       GENBANK/X51929
 AB    PCR amplification of baboon endogenous virus (BaEV) long terminal
       repeat, reverse transcriptase gene, and env fragments from 24 different
       species of African monkeys indicates that BaEV is less widespread than
       was formerly thought. Instead of being present in every species of
       African primates, BaEV can be found only in baboons, geladas, and
       mangabeys (all belonging to the Papionini tribe) and in African green
       monkey (Cercopithecus aethiops)subspecies. BaEV, which can be activated
       from baboon and gelada tissues, was most likely introduced in the germ
       line only recently (less than a few million years ago) and has not been
       inherited from a common ancestor of all extant African monkeys.
       Neighbor-joining and maximum-likelihood analyses of the sequences
       obtained showed that two distinct virus clusters can be distinguished:
       the first containing baboon, gelada, and African green monkey BaEV
       sequences and the second consisting of mandrill and mangabey BaEV
       sequences. This viral evolutionary tree does not follow host phylogeny,
       indicating the cross-species transmissions and multiple germ line
       fixations of the virus must have occurred in the past. BaEV sequences
       are found in monkeys inhabiting savannas (baboons, geladas, and African
       green monkeys) as well as forests (managabeys and mandrills) and cluster
       according to the habitats of their hosts, providing evidence for
       cross-species transmission in shared habitats.
 DE    Amino Acid Sequence  Animal  Base Sequence  Cercopithecidae/*VIROLOGY
       Cercopithecus aethiops/*VIROLOGY  Comparative Study  DNA Primers  DNA,
       Viral/BLOOD/GENETICS/ISOLATION & PURIF  Genes, env  Molecular Sequence
       Data  Papio/*VIROLOGY  *Phylogeny  Polymerase Chain Reaction  Repetitive
       Sequences, Nucleic Acid
       Retroviridae/CLASSIFICATION/*GENETICS/*ISOLATION & PURIF  RNA-Directed
       DNA Polymerase/CHEMISTRY/*GENETICS  Sequence Homology, Amino Acid
       Sequence Homology, Nucleic Acid  Social Behavior  Species Specificity
       Support, Non-U.S. Gov't  Theropithecus gelada/VIROLOGY  Viral Envelope
       Proteins/CHEMISTRY/*GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

