       Document 0520
 DOCN  M9630520
 TI    Diversity in virus populations from genital secretions and peripheral
       blood from women recently infected with human immunodeficiency virus
       type 1.
 DT    9603
 AU    Poss M; Martin HL; Kreiss JK; Granville L; Chohan B; Nyange P; Mandaliya
       K; Overbaugh J; Department of Microbiology, University of Washington,
       Seattle; 98195, USA.
 SO    J Virol. 1995 Dec;69(12):8118-22. Unique Identifier : AIDSLINE
       MED/96079070
 AB    In order to develop a human immunodeficiency virus type 1 vaccine with
       global efficacy, it is important to evaluate the virus populations that
       are transmitted to individuals living in high-incidence areas. To
       determine the nature of the human immunodeficiency virus type 1
       population transmitted to women during heterosexual contact, we examined
       the diversity of the proviral envelope gene in infected cells in both
       genital secretions and peripheral blood from six recently seroconverted
       Kenyan women. Heterogeneous virus populations were present in cervical
       secretions and/or peripheral blood shortly after seroconversion for five
       of six infected individuals, and tissue-specific variants were
       identified in several cases.
 DE    Amino Acid Sequence  AIDS Vaccines  Base Sequence  Cervix
       Uteri/SECRETION/*VIROLOGY  Cohort Studies  DNA Primers  DNA,
       Viral/*ANALYSIS/GENETICS  Female  Gene Products, env/CHEMISTRY/*GENETICS
       Genes, env  Human  HIV Seropositivity/*VIROLOGY
       HIV-1/*GENETICS/*ISOLATION & PURIF  Kenya  Lymphocytes/VIROLOGY  Male
       Molecular Sequence Data  *Phylogeny  Polymerase Chain Reaction
       Prostitution  Proviruses/GENETICS/ISOLATION & PURIF  Sequence Homology,
       Amino Acid  Support, U.S. Gov't, P.H.S.  *Variation (Genetics)  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

