       Document 0516
 DOCN  M9630516
 TI    Roles of different T-cell subsets in control of herpes simplex virus
       infection determined by using T-cell-deficient mouse-models.
 DT    9603
 AU    Manickan E; Rouse BT; Department of Microbiology, College of Veterinary
       Medicine,; University of Tennessee, Knoxville 37996-0845, USA.
 SO    J Virol. 1995 Dec;69(12):8178-9. Unique Identifier : AIDSLINE
       MED/96079083
 AB    Herpes simplex virus infection of the scarified dermis results in
       infection of the nervous system and, subsequently, a cutaneous lesion in
       the innervated dermatome. We compared the pathogenesis of such
       zosteriform lesions in mice lacking or severely depleted of CD4+ or CD8+
       T cells because of targeted gene disruption. Mice without CD4+ cells
       showed markedly increased susceptibility, whereas beta 2 microglobulin
       knockout mice lacking CD8+ T cells were as resistant to challenge as
       were immunocompetent mice with the same genetic background. Our results
       demonstrate that CD4+ T cells are of primary importance in the control
       of herpes simplex virus infections of the skin and nervous system.
 DE    beta 2-Microglobulin/DEFICIENCY/IMMUNOLOGY  Animal  Comparative Study
       CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Disease Susceptibility  Herpes
       Genitalis/*IMMUNOLOGY  Herpes Simplex/*IMMUNOLOGY  *Herpesvirus 1,
       Human/PATHOGENICITY  *Herpesvirus 2, Human/PATHOGENICITY  Mice  Mice,
       Inbred C57BL  Mice, Knockout  Species Specificity  Support, U.S. Gov't,
       P.H.S.  T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

