       Document 0513
 DOCN  M9630513
 TI    [A comparative study of the clinical and histological characteristics
       between classic nemaline myopathy and that associated with the human
       immunodeficiency virus]
 DT    9603
 AU    Miro O; Masanes F; Pedrol E; Garcia-Carrasco M; Mallolas J; Casademont
       J; Grau JM; Servicio de Medicina Interna General, Hospital Clinic i;
       Provincial, Barcelona.
 SO    Med Clin (Barc). 1995 Oct 21;105(13):500-3. Unique Identifier : AIDSLINE
       MED/96077776
 AB    BACKGROUND: Several cases of nemaline myopathy (NM) have been described
       in patients with human immunodeficiency virus (HIV) infection. The
       clinical and histological characteristics of classical NM are known, but
       remain to be defined in HIV positive patients. METHODS: A retrospective
       review of the NM over a 12-year period (1982-1993) was carried out. The
       clinical and histological data of the classical NM were compared with
       those associated to the HIV. RESULTS: Eight cases of NM were collected:
       five in HIV negative patients (classical NM) and three in HIV positive
       patients. The latter patients with NM were all males with no family
       history of myopathy. Motor development had been normal and was not
       associated with disorders in other systems and the muscular symptoms
       were slight. On muscle biopsy a lower percentage of fibers with nemaline
       bodies and type 2 muscle fiber atrophy were observed, as well as slight
       alterations in the oxidative reactions. A second muscle biopsy performed
       two years after in one of these patients was normal. Females
       predominated in the group of HIV negative patients with family history,
       motor retardation during infancy and different extramuscular alterations
       being frequent. The muscle symptoms were more marked and severe in the
       two cases with respiratory musculature involvement. Histologic study
       demonstrated a higher percentage of nemaline bodies, predominance of
       type 1 muscle fiber atrophy and frequent alterations in the oxidative
       reactions. CONCLUSION: Nemaline myopathy presented in patients with HIV
       infection differs from the classically described form. The presence of
       nemaline bodies on muscle biopsy in HIV positive patients may be
       interpreted more as an epiphenomenon in relation with HIV infection than
       as a primary myopathy.
 DE    Adult  Biopsy  Comparative Study  English Abstract  Female  Human  HIV
       Infections/COMPLICATIONS/*DIAGNOSIS/PATHOLOGY  *HIV-1  Male
       Muscles/PATHOLOGY  Nemaline
       Myopathy/*DIAGNOSIS/ETIOLOGY/GENETICS/PATHOLOGY  Retrospective Studies
       Sex Characteristics  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

