       Document 0506
 DOCN  M9630506
 TI    Increased expression of activation markers on CD8 lymphocytes in
       children with human immunodeficiency virus-1 infection.
 DT    9603
 AU    Schlesinger M; Peters V; Jiang JD; Roboz JP; Bekesi JG; Ruttenberg
       Cancer Center, T. J. Martell Laboratory for Leukemia,; Cancer and AIDS
       Research, Mount Sinai School of Medicine, New; York, New York 10029,
       USA.
 SO    Pediatr Res. 1995 Sep;38(3):390-6. Unique Identifier : AIDSLINE
       MED/96027083
 AB    The aims of the present study were to analyze the impact of perinatal
       human immunodeficiency virus (HIV)-1 infection on lymphocyte maturation
       in children, to determine the expression of activation markers on CD8+
       cells, and to define predictors of survival in HIV-infected children.
       Seventy-one children presenting HIV-related symptoms were included in
       the study; 29 were less than 2 y old and 42 were 2 to 12 y of age.
       Results were compared with those obtained in normal children of a
       similar age. In HIV-infected children the proportion of CD4+ and
       CD8+CD45RA+ cells was significantly decreased, whereas that of CD8+,
       CD8+CD38+, and CD8+CD45RO+ cells was strikingly increased compared with
       controls. In children less than 2 y old the absolute number of CD4+ and
       CD8+CD45RA+ cells decreased, and the number of CD8+CD45RO+ cells
       increased significantly, whereas the number of CD8+ and CD8+CD38+ cells
       did not change. The absolute number of CD4+ T cells declined with age
       both among controls and among HIV-infected children. In contrast, the
       absolute number of CD8+ cells and CD8 subsets decreased with age only in
       controls but not in infected children. In HIV-1-infected children the
       expression of the CD38 and CD45RO markers on CD8+ cells was
       significantly correlated, indicating that these were activated cells.
       The survival of less than 2-y-old children with AIDS symptoms was
       positively correlated with the total number of CD8 cells and CD8+CD38+
       cells at time of entry into the study.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/TRANSMISSION  Antigens,
       CD/ANALYSIS  Biological Markers/BLOOD  Child  Child, Preschool
       Comparative Study  CD4 Lymphocyte Count  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Disease Transmission, Vertical  Female  Human
       *HIV-1  Immunophenotyping  Infant  Lymphocyte Count  Lymphocyte Subsets
       *Lymphocyte Transformation  Phenotype  Pregnancy  Pregnancy
       Complications, Infectious  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

