       Document 0496
 DOCN  M9630496
 TI    AIDS: a disease of impaired Th-cell renewal?
 DT    9603
 AU    Heeney JL; Dept of Virology, Biomedical Primate Research Centre,
       Rijswijk,; The Netherlands.
 SO    Immunol Today. 1995 Nov;16(11):515-20. Unique Identifier : AIDSLINE
       MED/96084509
 AB    Individuals who are infected with human immunodeficiency virus (HIV) and
       develop AIDS are characterized by the progressive loss of T helper (Th)
       cells, together with an increase in virus load. Despite a remarkable
       similarity to humans, and their susceptibility to persistent HIV-1
       infection, chimpanzees have a relative resistance to the development of
       AIDS. Here, Jonathan Heeney proposes that the critical underlying event
       perpetuating the progression to AIDS is the impairment of the
       immunological microenvironment necessary for competent,
       antigen-specific, Th-cell renewal. Survival is dependent on the host's
       ability to preserve the immunological infrastructure sufficiently in
       order to maintain the capacity for renewal of a balanced, competent
       Th-cell population.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/*PATHOLOGY  Animal  Cell
       Differentiation  Human  Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

